Optically pumped magnetometers (OPMs) have recently become so sensitive that they are suitable for use in magnetoencephalography (MEG). These sensors solve operational problems of the current standard MEG, where superconducting quantum interference device (SQUID) gradiometers and magnetometers are being used. The main advantage of OPMs is that they do not require cryogenics for cooling. Therefore, they can be placed closer to the scalp and are much easier to use. Here, we measured auditory evoked fields (AEFs) with both SQUID- and OPM-based MEG systems for a group of subjects to better understand the usage of a limited sensor count OPM-MEG. We present a theoretical framework that transforms the within subject data and equivalent simulation data from one MEG system to the other. This approach works on the principle of solving the inverse problem with one system, and then using the forward model to calculate the magnetic fields expected for the other system. For the source reconstruction, we used a minimum norm estimate (MNE) of the current distribution. Two different volume conductor models were compared: the homogeneous conducting sphere and the three-shell model of the head. The transformation results are characterized by a relative error and cross-correlation between the measured and the estimated magnetic field maps of the AEFs. The results for both models are encouraging. Since some commercial OPMs measure multiple components of the magnetic field simultaneously, we additionally analyzed the effect of tangential field components. Overall, our dual-axis OPM-MEG with 15 sensors yields similar information to a 62-channel SQUID-MEG with its field of view restricted to the right hemisphere.

Magnetoencephalography (MEG) is a neuroimaging technique that measures the magnetic fields of the brain outside of the head. In the past, the most suitable magnetometer for MEG was the superconducting quantum interference device (SQUID), but in recent years, a new type has also been used, the optically pumped magnetometer (OPM). OPMs can be configured to measure multiple directions of magnetic field simultaneously. This work explored whether combining multiple directions of the magnetic field lowers the source localization error of brain sources under various conditions of noise. We simulated dipolar-like sources for multiple configurations of both SQUID- and OPM-MEG systems. To test the performance of a given layout, we calculated the average signal-to-noise ratio and the root mean square of the simulated magnetic field; furthermore, we evaluated the performance of the dipole fit. The results showed that the field direction normal to the scalp yields a higher signal-to-noise ratio and that ambient noise has a much lower impact on its localization error; therefore, this is the optimal choice for source localization when only one direction of magnetic field can be measured. For a low number of OPMs, combining multiple field directions greatly improves the source localization results. Lastly, we showed that MEG sensors that can be placed closer to the brain are more suitable for localizing deeper sources.

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Some optically pumped magnetometer (OPM) sensors available for biomagnetic investigations have a linear range limited to +- 1 nT due to the specific properties of their open loop operation. In a two-layer magnetically shielded room of type Ak3b/Vacoshield Advanced with an external active compensation we studied how much sensor movement is allowed until amplitudes exceed the linearity range. Intentional movements were performed by a subject wearing an OPM-MEG sensor array. It was found that movements of 8 cm did yield non-linear amplitudes, but a reduction of the movement in half already preserves linearity. Despite movements, the heartbeat was found to generate a periodic signal, although the generating mechanism could not be identified so far.