Background: The incidence of pulmonary fungal infections in patients with COVID-19 disease is not well described. Isolation and identication of these infections may improve patient's outcome. Therefore, the objective of the study is to nd out the incidence of pulmonary fungal co- infections and to isolate and identify the fungal pathogens in COVID positive patients. Methods: This retrospective observational study was conducted at Tejas Microdiagnostics during 30 April 2021 to 30 June 2021. A total of 59 patients with severe COVID-19 infection requiring admission in SRN Hospital, Prayagraj were included in the study. Sputum specimen was sent for culture and sensitivity to Tejas Microdiagnostics within eight hours of admission for the evaluation of fungal infections. Results: Out of 59 COVID positive cases, 53 cases were identied with fungal infections. The mean age of patients with infections was 61.29 + 7.84 years with males being about 73.6% and females about 26.4%. The pulmonary fungal infection comprised of Candida glabrata (13.21%), Candida tropicalis (33.96%), Candida albicans (9.43%), Candida cruzi (15.09%), Candida parapsilosis (18.87) Mucour (3.77%), Penicillium (1.89%), Rhizopus (1.89%) Aspergilluss fumigatus (1.89). Mortality was observed in 7.5% cases. Conclusion: Our study illustrates that 89.8 % COVID positive patients were infected with pulmonary fungal infections. The reason for such a high incidence can be the wide spread use of empirical antibiotics and steroids which may increased the risk of fungal infections in patients with COVID-19. Isolation and identication of such infections is prudent and may reduce the morbidity and mortality of the patients.
Background: Candida species are major constituents of the human mycobiome and the main cause of invasive fungal infections, with a high mortality rate and recognized as a complication of severe COVID-19. The present study is an attempt to identify the etiological agents in blood samples of critically ill Covid positive patients so that timely interventions can be helpful to reduce morbidity and mortality in such patients. Material and method: This retrospective observational study was conducted at Tejas Microdiagnostics during 30 April 2021 to 30 June 2021. A total of 126 Covid positive patients requiring admission in SRN Hospital, Prayagraj were included. Blood specimen collected in FA and FAN bottles were sent for culture and antibiogram to Tejas Microdiagnostics within eight hours of admission. Blood culture of 89 (70%)Results: patients was positive while 37 (30%) patients did not show any growth. Fungi were isolated in 24(26.96%) cases while bacterial growth was identied in 65(73.04%) cases. Candida tropicalis was the most predominat species while Aspergillus fumigates and Penicillium were isolated among dimorphic fungi. Mortality was observed in 15% cases. Our study illustrates the predominance of Candida tropicalis fromConclusion: blood samples of Covid positive patients. This statistics may be the tip of the iceberg. The reason for such a high incidence can be the wide spread use of empirical antibiotics and steroids which may increased the risk of fungal infections in patients with COVID-19. Isolation and identication of pathogens are prudent and may reduce the morbidity and mortality of the patients.
Background: Bloodstream infections are an emerging cause of signicant morbidity and mortality in critically ill COVID-19 patients. The present study was designed to evaluate the incidence of BSI and to identify its causative agents in critically ill Covid positive patients to provide targeted therapy to improve the outcome in such patients. This retrospective observational study was conducted at Tejas Microdiagnostics during 30Material and method: April 2021 to 30 June 2021. A total of 126 Covid positive patients requiring admission in SRN Hospital, Prayagraj were included. Blood specimen collected in FA and FAN bottles were sent for culture and antibiogram to Tejas Microdiagnostics within eight hours of admission. Blood culture of 89 (70%) patients was positive while 37 (30%) patients did not show any growth.Results: Bacterial growth was identied in 65 (73.04%) cases while fungi were isolated in 24 (26.96%) cases. Acinatobacter was identied in single patient. Klebsiella pneumoneae (19.23%) and Staphylococcus aureus (15.38%) were the predominant gram negative and gram positive aerobes while Fusobacterium (46.15%) and Peptococcus (15.38%) was gram negative and gram positive anaerobes. Mortality was observed in 21% cases. Our study emphasizes that blood stream infectionsConclusion: appeared to be the signicant cause of morbidity and mortality in Covid positive patients. The reason of infections can be the wide spread use of empirical antibiotics and steroids which may increased the risk of antibiotic drug resistance and treatment failure. Therefore to reduce morbidity and mortality we have to ensure rapid Isolation and species identication in such patients.
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