Aim: Resistance to methicillin and Macrolide–Lincosamide and Streptogramins B and their association with erm genes in Staphylococcus aureus are unknown in Nepal. Materials & methods: Nonduplicate nasal swabs from 160 school children were collected from April to September 2018 and processed using standard microbiological procedures. Results: Out of 160 samples, 64 (40%) were S. aureus in which 17 (26.6%) were methicillin-resistance Staphylococcus aureus (MRSA). D-test identified 15 (23.4%) as inducible clindamycin-resistant, which were more prevalent in MRSA (76.4%) than methicillin-sensitive S. aureus (MSSA; 4.2%). 18.7% of isolates harbored the ermC gene followed by ermA (15.6%) and ermB (3.1%), and were more in MRSA than MSSA. Conclusion: To prevent treatment failure by inducible resistance, D-test must be performed on erythromycin-resistant and/or clindamycin-sensitive isolates.

Background. Low birth weight (LBW) is defined as the birth weight of live born infants below 2500 g, regardless of gestational age. It is a public health problem caused by factors that are potentially modifiable. The purpose of this study was to determine the socioeconomic, obstetric, and maternal factors associated with LBW in Lumbini Provincial Hospital, Nepal. Methods. The study was conducted using case control study design with 1 : 2 case control ratio. A total of 105 cases and 210 controls were taken in this study. Data were entered on Epi data software version 3.1 and exported to Statistical Package for Social Science (SPSS) software version 25 for analysis. Characteristics of the sample were described using mean and standard deviation. Bivariate analysis was done to assess the association between dependent and independent variables. The ultimate measure of association was odds ratio. Variables found to be associated with bivariate analysis were entered into a multivariable logistic regression model to identify predictors of LBW. Results. The mean age of the participants was 25.98 years with ±4.40 standard deviation. Mothers with literate educational background (AOR 0.32, 95% CI 0.13–0.81), housewife (AOR 2.63, 95% CI 1.11–6.20), vaginal mode of delivery (AOR 0.45, 95% CI 0.25–0.82), gestational age <37 weeks (AOR 2.51, 95% CI 1.15–5.48), history of LBW (AOR 5.12, 95% CI 1.93–13.60), and maternal weight <50 kilograms (AOR 2.23, 95% CI 1.23–4.02) were significantly associated with LBW. Conclusion. Educational and occupational status, mode of delivery, gestational age, maternal weight, and history of LBW were found to be independent predictors of LBW. There is need of developing coordination with education sector for increasing educational status of mothers and adolescent girls. Social determinants of health need to be considered while developing interventional programs. Similarly, interventional programs need to be developed considering identified predictors of low birth weight.

Quality protein maize (QPM) contains opaque-2 mutant genes that increases lysine and tryptophan level which are not normally found in maize. The objective of this study was to evaluate the performance of QPM genotype based on their yield, yield attributing and other relevant characteristics. A varietal trial on QPM was conducted in the research field of Lamahi municipality-3, Dang, Nepal from February to June 2021. This experiment was performed in Randomized Complete Block Design with three replications. Thirteen genotypes of QPM and one standard check (Poshilo Makai-2) were evaluated. Each genotype was assigned an area of 3m × 3m with a net plot area of 452.5m2 per block. Analysis of variance revealed significant data for the most of the genotypes. Four genotypes Rampur-S13FQ-02 Rampur-SO3FQ-02, Rampur-S13FQ010 and Rampur-S13FQ-08 were found superior with a yield of 4.32 t/ha, 3.97 t/ha, 3.89 t/ha, 3.63 t/ha respectively in comparison to the standard check Poshilo makai-2 (2.66 t/ha). Significant and positive correlation were observed for the ear length, ear diameter, number of kernels per ear, number of kernel row per ear, ear weight whereas negative for ear aspect with grain yield was observed. Ear weight without husk had the highest contribution to grain yield. For all observed traits, the coefficient of phenotypic variation (PCV) was found to be higher than that of genotypic coefficient of variation (GCV). The highest GCV, PCV, genetic advance and heritability were observed in ear aspect, thousand grain weight, ear height, plant height respectively. As a result, breeding programs can be further improved by selecting these traits.