No abstract

Twenty-two new methyl (ethyl) 2,6,6-or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydro-quinoline-3-carbohydrates and 12 new N-N-diethyl 2,6,6 or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives are synthesized and their activity on calcium channel antagonists was observed. Synthesis was done by the Hantzsch reaction. Calcium antagonistic activity was determined by tests performed on isolated rat ileum and thoracic arteries.