Background. Muscle synergy analysis is an approach to understand the neurophysiological mechanisms behind the hypothesized ability of the Central Nervous System (CNS) to reduce the dimensionality of muscle control. The muscle synergy approach is also used to evaluate motor recovery and the evolution of the patients’ motor performance both in single-session and longitudinal studies. Synergy-based assessments are subject to various sources of variability: natural trial-by-trial variability of performed movements, intrinsic characteristics of subjects that change over time (e.g., recovery, adaptation, exercise, etc.), as well as experimental factors such as different electrode positioning. These sources of variability need to be quantified in order to resolve challenges for the application of muscle synergies in clinical environments. The objective of this study is to analyze the stability and similarity of extracted muscle synergies under the effect of factors that may induce variability, including inter- and intra-session variability within subjects and inter-subject variability differentiation. The analysis was performed using the comprehensive, publicly available hand grasp NinaPro Database, featuring surface electromyography (EMG) measures from two EMG electrode bracelets. Methods. Intra-session, inter-session, and inter-subject synergy stability was analyzed using the following measures: variance accounted for (VAF) and number of synergies (NoS) as measures of reconstruction stability quality and cosine similarity for comparison of spatial composition of extracted synergies. Moreover, an approach based on virtual electrode repositioning was applied to shed light on the influence of electrode position on inter-session synergy similarity. Results. Inter-session synergy similarity was significantly lower with respect to intra-session similarity, both considering coefficient of variation of VAF (approximately 0.2–15% for inter vs. approximately 0.1% to 2.5% for intra, depending on NoS) and coefficient of variation of NoS (approximately 6.5–14.5% for inter vs. approximately 3–3.5% for intra, depending on VAF) as well as synergy similarity (approximately 74–77% for inter vs. approximately 88–94% for intra, depending on the selected VAF). Virtual electrode repositioning revealed that a slightly different electrode position can lower similarity of synergies from the same session and can increase similarity between sessions. Finally, the similarity of inter-subject synergies has no significant difference from the similarity of inter-session synergies (both on average approximately 84–90% depending on selected VAF). Conclusion. Synergy similarity was lower in inter-session conditions with respect to intra-session. This finding should be considered when interpreting results from multi-session assessments. Lastly, electrode positioning might play an important role in the lower similarity of synergies over different sessions.

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Long-term monitoring of patients with epilepsy presents a challenging problem from the engineering perspective of real-time detection and wearable devices design. It requires new solutions that allow continuous unobstructed monitoring and reliable detection and prediction of seizures. A high variability in the electroencephalogram (EEG) patterns exists among people, brain states, and time instances during seizures, but also during non-seizure periods. This makes epileptic seizure detection very challenging, especially if data is grouped under only seizure (ictal) and non-seizure (inter-ictal) labels. Hyperdimensional (HD) computing, a novel machine learning approach, comes in as a promising tool. However, it has certain limitations when the data shows a high intra-class variability. Therefore, in this work, we propose a novel semi-supervised learning approach based on a multi-centroid HD computing. The multi-centroid approach allows to have several prototype vectors representing seizure and non-seizure states, which leads to significantly improved performance when compared to a simple single-centroid HD model. Further, real-life data imbalance poses an additional challenge and the performance reported on balanced subsets of data is likely to be overestimated. Thus, we test our multi-centroid approach with three different dataset balancing scenarios, showing that performance improvement is higher for the less balanced dataset. More specifically, up to 14% improvement is achieved on an unbalanced test set with 10 times more non-seizure than seizure data. At the same time, the total number of sub-classes is not significantly increased compared to the balanced dataset. Thus, the proposed multi-centroid approach can be an important element in achieving a high performance of epilepsy detection with real-life data balance or during online learning, where seizures are infrequent.

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