Background: Pregnancy and puerperium are most prevalent prothrombotic states leading to cerebral venous thrombosis (CVT). Pregnancy induces several changes in coagulation system, which persists at least during early puerperium, rendering it a prothrombotic state. The objective of the study was to study the clinical profile of postpartum CVT.Methods: A total of 32 consecutive patients admitted in medicine and obstetrics and gynecology ward between April 2012 and March 2015 with radiologically confirmed diagnosis of CVT were included in the study. Detailed history, clinical examination, and laboratory investigations were carried out in all the cases.Results: Out of 32 patients of CVT studied, the age of patients varied from 18 to 40 years. Maximum incidence was seen in 21-30 age group comprising 74% of the cases, with mean age being 25.5 years. Two-third of the patients belongs to the low socio-economic class. The majority of them had subacute presentation with the headache in 93.75%, followed by altered sensorium (90.6%) and convulsions (75%) being the most common presenting symptoms. Radiologically the most common finding noted was hemorrhagic infarction (85.3%), followed by non-hemorrhagic infarction (15.7%).Conclusions: Pregnancy and puerperium are most prevalent prothrombotic states leading to CVT.
Background:Hypertension on a long-term basis can cause target organ damage, especially the central nervous system, which can affect cognition. It is known that difference between simple and choice reaction time (RT) implies time required for cognition. Although delayed RTs indicate involvement of cognition, they cannot quantify how much time is required for cognition.Aim:Recording chronoscpic RT to quantify time required for cognition in hypertensives and compare them with controls.Subjects and Methods:This is a hospital-based case–control study conducted (August 2010 to January 2011) on 118 subjects attending an outpatient department using visual and whole body reaction timers having criteria of age and hypertensive condition, compared with an equal number of age- and sex-matched controls. Statistical analysis was carried out by Independent t test and duration of hypertension was correlated with whole body choice reaction time (WBCRT) C1 using Pearson's correlation. Predictive value of WBCRT C1 was calculated by using the receiver operating characteristic curve.Results:The WBCRT C1 562.6 (108) ms was more delayed among hypertensives compared with controls 523.5(98.8) ms. There was no significant correlation between duration of hypertension and WBCRT C1 (r = -0.064). The best cut-off value for WBCRT C1when predicting cognitive dysfunction in hypertensive patients was 538.5 ms (sensitivity 76.2%, specificity 50%).Conclusions:WBCRT C1 can be a quantitative measurement of cognition. It can be used as a screening tool to detect cognitive dysfunction.
Background: Human immunodeficiency virus (HIV) infection is characterized by decrease in CD4 cell count and immunodeficiency, leading to opportunistic infections (OIs) and tumors. Objective of this study was to find out any association between thyroid function abnormality and CD4 count, duration of disease and ART drugs.Methods: Among 300 HIV/AIDS Persons attending ART centre, M.Y. Hospital, or attending general OPD, or admitted as in patients Dept. of Medicine, MGM Medical College and M.Y. Hospital, Indore, India.Results: Amongst 300 HIV patients,62 (20.66%) had thyroid dysfunction, most common being subclinical hypothyroidism (24/300, 8.0%) followed by sick euthyroid (17/300, 5.6%) and subclinical hyperthyroidism (13/300, 4.3%). Overt hypothyroidism was present in 5 of 300 (1.66%) patients and overt hyperthyroidism was present in 3 of 300 (1.0%) patients. 25 of 152 (16.44%) and 37 of 148 (25%) male and female HIV patients had thyroid function abnormality. Thyroid dysfunction was significantly more observed in old HIV patients (42/150, 28.0%) than in newly diagnosed HIV patient’s group (20/150, 13.33%).Conclusions: This prevalence being fairly high, it can be suggested that all retro positive patients, recently diagnosed and on treatment also may be subjected for routine thyroid function testing.
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