Considering rising number of older people worldwide, provision of quality healthcare services has become matter of concern. Since, healthcare practitioners’ attitudes towards ageism affect quality of the care provided to the older population. Objective: To evaluate the ageism attitude of clinical physical therapists towards older people. Methods: A cross sectional study was conducted at various public and private sector clinical settings in Faisalabad. 118 participants who were clinical physical therapists with at least one-year clinical experience, currently practicing and willing to participate were included. Geriatrics attitude scale and facts on aging scale were used as outcome measures. SPSS (V.24) was used for analyzing the data and results were interpreted using frequency tables and chi square. Results: The 83.1% participants belonging to age group 24-30 years while 79.7% were female physical therapists.80.5% had been working for more than one year. Attitude was measured with GAS at once time. 68.5% of the people gave positive attitude toward older people. Knowledge was measured with FAQ scale at once time. 51.1% of the participants have maximum knowledge about older people. Interpretation of chi square showed there was no correlation between attitude and knowledge of the physical therapy clinicians (p > 0.05). Conclusion: This study concluded that clinical physical therapists were bearing positive attitude towards older people being aware of the ageism facts. However, there was no correlation found between clinician’s knowledge and ageism attitude
Cerebral palsy (CP) is one of the most prevalent childhood-onset causes of permanent disability affecting gross motor functioning and postural control ability. Objective: To determine the effects of neurodevelopmental treatment on the gross motor function postural control among children with spastic CP. Methods: A single-blinded randomized controlled trial was carried out at Sher e Rabbani Hospital, Department of Pediatric Rehabilitation, Sheikhupura. 66 children fulfilling the inclusion criteria were recruited using the non-probability sampling technique. Participants were divided into two groups, Group A which received beuro developmental techniques along with routine physical therapy while Group B received only routine physical therapy treatment. To collect data, Gross motor function measure scale (GMFM-88) and posture and postural ability scale (PPAS) were employed as outcome measures. Results: Repeated measure ANOVA and an independent t-test were executed for parametric data after assuming normality. Pairwise comparison of both groups demonstrated that gross motor function was significantly improved from baseline to 4th, 8th, and 12th week after applying NDT treatment (p-value≤ 0.05). Pairwise comparison of both groups revealed that postural ability post NDT treatment and significant improvement was observed after 12 weeks in comparison to baseline. While within-group comparison at different follows up for gross motor function measure and postural control also expressed p≤ 0.05 as significant. Conclusions: Children with spastic CP who received Neurodevelopmental Therapy along with conventional physical therapy treatment showed significant improvements in gross motor function and postural control as compared to the control group.
Targeting EGFR has been effective in RAS/RAF wild-type colorectal cancer (CRC) patients. However, residual tumor relapses, necessitating the importance of biomarker-guided novel therapeutics. We show elevated DKC1 in ~88% of CRC patients with poor recurrence-free survival. Clinically, DKC1-positive patients exhibit similarity with CMS2 class, the canonical subtype with active WNT signaling. We show functional significance of DKC1 in cell proliferation, stemness, DNA repair, and survival. Further, mice bearing DKC1 knockdown xenografts show ~81% reduction in tumor burden. Mechanistically, WNT/beta-catenin signaling orchestrates DKC1 expression, then, DKC1/SOX2 complex regulates SGPP2, modulating sphingolipids metabolism. Downregulation of DKC1 in CRC lead to reduced SGPP2 levels leading to dysregulation of sphingolipid biosynthesis. Of note, DKC1-high CRC patients show accumulation of ceramides, namely C23 and C24, signifying their utility in diagnosis. Collectively, we delineate the mechanistic circuitry involved in DKC1-mediated CRC progression, propose ceramides as biomarker, and underscore WNT-based therapeutics for DKC1-positive patients.
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