The COVID-19 disease initially originated in Wuhan (China) and then spread worldwide has been declared a pandemic by the World Health Organization (WHO). Many attempts are ongoing to find an effective therapeutic treatment and vaccine to cure or prevent the disease, but the success is very little. Even some of the approved vaccines are also disputed for safety issues. This is the time where we should think of alternative treatments to control the disease effectively. Photodynamic therapy (PDT) is a technique that is widely used in cancer treatment and against various microbes. In this technique, a light-induced photosensitizer generates reactive oxygen species (ROS), ultimately killing the target cells. Considering these facts, an attempt has been made to review the current literature on viral inactivation using PDT approach. Accordingly, the mechanism of PDT action has been discussed, along with an update on the use of various photosensitizers (PSs) and nanoparticles. The capsid proteins and nucleic acid (RNA) of SARS-CoV-2 can be a possible target for PDT. To understand this interaction further, computational modeling studies have been discussed to help design effective PSs. Overall, the PDT technique has therapeutic potential and should be tested as a complementary or alternative treatment for control of COVID-19 using the PSs like curcumin, psoralen derivatives, riboflavin, etc. This review discusses COVID-19, its outbreak, diagnosis, the existing treatment modalities, and how PDT can be an effective alternative treatment for controlling the disease.
The Srotas are well defined concept explained by Acharya Sushruta and Charak; Udakvaha Srotas is one of them. Its root source (Moolsthan) is Talu & Kloma. The root source Talu of Udakvaha Srotas is well known and understood as palate everywhere but still there is ambiguity about Kloma. The thirst (Pipasa) is prime symptom of interruption in Udakvaha Srotas similarly thirst is also found in chronic obstructive pulmonary disease (COPD) cases, therefore it would be possible to study the role of lungs in maintenance of water in the body. So, this was primary effort to study the structure Kloma in the body with the help of observational study i.e. by observing Pipasa in cases of COPD considering the lung as a controversial structure Kloma. Secondary objectives of the study were literature search about Kloma, study of Viddha Lakshana and correlation of Kloma with present well-known structure. So to explain the anatomical area of Kloma and specify Kloma with body organ was the prime plan to start this review.
The most common primary malignancies that affect the pericardium are lung cancers. Typically, pericardial involvement stays undiagnosed, with almost 1-20% of all tumor-related autopsies revealing invasion of the pericardium. Pericardial effusions are seldom the first location of metastasis and presentation of a primary malignancy. Malignant pericardial effusions are usually silent, although they cause dyspnea, chest discomfort, arrhythmias, cough, and, in rare cases, pericardial tamponade. In a patient with tamponade, a high index of tumor-related suspicion is crucial to rule out cancer. Emergency pericardiocentesis is indicated based on the clinical presentation, however, the patient frequently has a bad prognosis regardless of whether treatment is administered or not. In this case series, we report five cases of non-small cell lung cancer (NSCLC) with pericardial effusion as an initial presentation.
Pulmonary involvement complicates the various aspects of care in patients suffering from autoimmune disorders. The epidemiological data generated over the last 10 to 15 years have improved the overall understanding of the risk factors and pathophysiological mechanisms involved in pulmonary involvement in rheumatological conditions. Recent advances in genetics have provided superior insight into the pathogenesis of autoimmune diseases and the underlying pulmonary involvement. This review article provides a concise overview of the four most common rheumatological conditions associated with pulmonary involvement: systemic lupus erythematosus (SLE), dermatomyositis/polymyositis, rheumatoid arthritis (RA), and systemic sclerosis (SSc). The clinical, epidemiological, and genetic aspects of these diseases are summarized in this article with particular emphasis on the characteristic patterns of pulmonary involvement in radiological imaging and various treatment options for each of these autoimmune diseases and their lung manifestations.
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