Objective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in reproductive women. Cardiovascular disease risk factors are more frequent in this population. We aimed in this study to investigate presence of QT dispersion and effects of sex hormones and insulin on QT duration in young PCOS patients. Methods: This present study was cross-sectional observational study. A total of 47 women, 25 patients with PCOS and 22 healthy, were included. Serum testosterone, estradiol and insulin levels were studied and electrocardiography was performed at 2 nd or 3 th days of menstrual cycle. The study population was divided into groups according to serum testosterone and estradiol levels. Sub-groups and pairwise groups were compared by Mann-Whitney U or student t-test. The associations of QTc durations with hormone levels were calculated using Spearman rank correlation analysis. The results were evaluated at the p<0.05 significance level. Results: No differences found between groups regarding to demographic parameters. Estradiol and testosterone levels were higher in patients with PCOS (41.12±13.59 vs. 35.57±19.29 pg/mL, p=0.09 and 105±58.5 vs. 17.6±10.9 ng/dL, p=0.01, respectively). QT dispersion was significantly longer in PCOS patients (47.1 vs. 32.7 ms, p=0.01). A positive correlation was found between the serum insulin level and QTc min, QTc max, and QTc mean (r=0. 402, p=0.011; r=0.341, p=0.033; r=0.337, p=0.036; respectively). QT dispersion with serum testosterone and estradiol levels were positively correlated (r=0.525, p=0.001and r=0.326, p=0.046; respectively). Conclusion: Our results suggest that QT dispersion is prolonged and testosterone, estradiol and insulin are associated with QT duration in young PCOS patients. (Anadolu Kardiyol Derg 2013; 13: 772-7) Key words: Electrocardiography, QT dispersion, polycystic ovary syndrome, insulin resistance, insulin Original Investigation Özgün Araşt›rma 772ÖZET Amaç: Polikistik over sendromu (PKOS) reprodüktif dönemdeki kadınlarda sık karşılaşılan bir endokrinopatidir. PCOS hastalarında kardiyovasküler hastalık risk faktörleri sık görülür. Bu çalışmada PCOS tanısı alan genç kadınlarda QT dispersiyonu varlığını ve gonadal hormonlar ve insülinin QT süresi üzerine etkilerini araştırmayı amaçladık. Yöntemler: Gözlemsel ve enine kesitli bu çalışmaya PKOS tanısı alan 25 hasta ve kontrol grubu olarak 22 sağlıklı olmak üzere toplam 47 kadın dahil edildi. Serum testosteron, östrojen ve insülin düzeyleri, elektrokardiyografik ölçümler menstrürasyon döngüsünün 2. veya 3. gününde yapıldı. HOMA-IR hesaplandı. Çalışma olguları östrojen ve testosteron düzeylerine göre gruplara ayrıldı. İkili grupların karşılaştırılmasında student-t veya Mann-Whitney U testi kullanıldı. Testosterone, östrojen, insülin ve HOMA-IR düzeyleri ile QT süreleri arasındaki ilişkinin değer-lendirilmesinde Spearman rank korelasyon analizi kullanıldı. P değeri <0,05 anlamlı kabul edildi. Bulgular: Gruplar arasında demografik özellikler bakımından fark yoktu. Östrojen düzeyi ve testosteron düzeyleri ...
Shockwave lithotripsy has an apoptotic effect on renal tubular cells that can be detected 4 weeks after the procedures, but no apoptotic effect on glomerular cells. Treatment with SWL also attenuates the proliferation of both tubular and glomerular cells.
Introduction The purpose of this report was to describe a very rare case of simultaneous bilateral quadriceps tendon rupture seen in a patient who was diagnosed as having diffuse idiopathic skeletal hyperostosis. Case Presentation A man aged 64 years presented to the emergency department with bilateral quadriceps tendon rupture. Surgical repair was performed with suture anchors and a stainless steel cable. His legs were immobilized in casts for six weeks. After removal of the casts, physiotherapy was started. Four months after surgery, he was able to walk with 0°–120° range of motion and active extension. He was followed up for 8 years without rerupture or other complications. Conclusion Bilateral rupture of the quadriceps tendon is a rare condition and generally related to metabolic disorders. Diffuse idiopathic skeletal hyperostosis is a metabolic disorder that causes bilateral quadriceps tendon rupture, and it accounted for the differential diagnosis of the underlying condition.
SummaryObjectiveThe aim of this study was to evaluate atrial conduction abnormalities obtained by tissue Doppler imaging (TDI) and electrocardiogram analysis in pregnant subjects.MethodsA total of 30 pregnant subjects (28 ± 4 years) and 30 controls (28 ± 3 years) were included. Systolic and diastolic left ventricular (LV) function was measured using conventional echocardiography and TDI. Inter-atrial, intra-atrial and intra-left atrial electromechanical coupling (PA) intervals were measured with TDI. P-wave dispersion (PD) was calculated from a 12-lead electrocardiogram.ResultsAtrial electromechanical coupling at the septal and left lateral mitral annulus (PA septal, PA lateral) was significantly prolonged in pregnant subjects (62.1 ± 2.7 vs 55.3 ± 3.2 ms, p < 0.001; 45.7 ± 2.5 vs 43.1 ± 2.7 ms, p < 0.001, respectively). Inter-atrial (PA lateral – PA tricuspid), intra-atrial (PA septum – PA tricuspid) and intra-left atrial (PA lateral – PA septum) electromechanical coupling intervals, maximum P-wave (Pmax) duration and PD were significantly longer in the pregnant subjects (26.4 ± 4.0 vs 20.2 ± 3.6 ms, p < 0.001; 10.0 ± 2.0 vs 8.0 ± 2.6 ms, p = 0.002; 16.4 ± 3.3 vs 12.2 ± 3.0 ms, p < 0.001; 103.1 ± 5.4 vs 96.8 ± 7.4 ms, p < 0.001; 50.7 ± 6.8 vs 41.6 ± 5.5 ms, p < 0.001, respectively). We found a significant positive correlation between inter-atrial and intra-left atrial electromechanical coupling intervals and Pmax (r = 0.282, p = 0.029, r = 0.378, p = 0.003, respectively).ConclusionThis study showed that atrial electromechanical coupling intervals and PD, which are predictors of AF, were longer in pregnant subjects and this may cause an increased risk of AF in pregnancy.
HighlightsIntraneural ganglion cysts are benign, mucinous, non-neoplastic lesions of the peripheral nerves that arise from the epineurium.An intraneural ganglion cyst involving the superficial branch of the ulnar nerve is a unique presentation.Regarding etiopathogenesis of the intraneural ganglion cysts, the latest and most affirmed theory is the unifying articular (synovial) theory.It is important to realize a related articular branch, otherwise the origin of cyst formation remains, and this may cause other para-articular cysts.Use of new 3-dimensional fast-spin echo-extended echo train MRI sequences may provide better visualization of the intraneural ganglions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.