Selenolato-bridged
manganese(I)-based dinuclear metallacycles [{(CO)3Mn(μ-SeC6H5)2Mn(CO)3}(μ-L)]
(1–4) were achieved in a
single-step process by the self-assembly of dimanganese decacarbonyl,
diphenyl diselenide, and flexible ditopic ester-functionalized pyridyl
ligands [1, L = o-phenylene diisonicotinate
(pdi); 2, L = 1,6-hexanediyl di-4-pyridine carboxylate
(hdp); 3, L = 4-pyridine carboxylic acid diethylene glycol
diester (pcadgd); 4, L = 4-pyridine carboxylic acid triethylene
glycol diester (pcatgd)]. Synthesis of a series of selenolato-bridged
dinuclear Mn(I)-based metallacycles was facilitated via oxidative
addition of C6H5Se–SeC6H5 to (CO)5Mn–Mn(CO)5 with simultaneous
coordination of flexible ditopic pyridyl linkers in an orthogonal
fashion. The metallacycles were characterized by IR, UV–vis,
NMR, and electrospray ionization-mass spectroscopic techniques and
elemental analysis. Solid-state structural elucidation of 3 was carried out using single-crystal X-ray diffraction methods.
In addition, anticancer activity studies were carried out for compounds 2–4 with various cancer cell lines. Furthermore, compound 3 was probed to evaluate its potential CO-releasing property
using myoglobin assay.
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