An efficient one pot synthesis of 2-arylbenzothiazole derivatives through condensation of aldehydes and 2-aminothiophenol in the presence of catalytic amount of La(NO 3 ) 3 ·6H 2 O under mild reaction conditions was developed. The key advantages of this protocol are short reaction time, high to excellent yields, simple work up, inexpensive catalyst and simple separation of pure product.
The present paper shows that lanthanum(III) nitrate hexahydrate can be used as mild and environment friendly homogeneous catalyst for an efficient one-pot multi-component synthesis of biologically active 1,8-dioxo-octahydroxanthene and 14H-dibenzo[a,j]xanthene derivatives. The solvent free condensation reaction of aromatic aldehydes and dimedone or β-naphthol was carried out at 70-80ºC during 10-30 min. The advantages of this eco-friendly synthesis route are numerous, and include the use of an inexpensive catalyst, high to excellent yield, short reaction time and high catalytic activity that can make this method an interesting alternative to multi-step approaches.
In the present investigation, a mild, efficient and simple procedure has been developed for the synthesis
of xanthene derivatives is described via three component condensation of aromatic aldehydes with β-
naphthol or dimedone or mixture of β-naphthol and dimedone using Brønsted acidic ionic liquid,
triphenyl(propyl-3-sulphonyl)phosphonium toluene-sulfonate under solvent-free conditions. The
synthesized compounds were screened for antimicrobial activities against Gram-positive (Bacillus subtilis),
Gram-negative (Pseudomonas aeruginosa) bacteria and fungus (Candida albicans). The antioxidant
activities of these compounds were determined by DPPH scavenging free radical method. Present
methodology has a number of advantages such as mild reaction condition, inexpensive catalyst, stable at
room temperature and it was also found that this catalyst might be recovered quantitatively and reused
without much loss of catalytic activity.
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