IntrOductIOnLung cancer is one of the most common malignancies with high mortality, 13% of all new cancer cases and 19% of cancer related deaths worldwide are due to lung cancer. A 6.9% of all new cancer cases and 9.3% of all cancer related deaths in India are due to lung cancer. The 5 year survival rate is only 15% in the developed countries and a dismal 5% in the developing countries [1].
Introduction: Diagnosis of sputum negative pulmonary tuberculosis can be challenging and time consuming, with many patients being put on empirical anti-tuberculosis treatment. Bronchoscopy helps in early diagnosis in such patients. Aims and Objectives: To assess the diagnostic utility of bronchial washing CBNAAT for Mycobacterium Tuberculosis in sputum smear negative and sputum CBNAAT negative patients of suspected pulmonary tuberculosis. Methodology: This case series was conducted on 71 patients in the Department of Pulmonary Medicine, Goa Medical College from May 2018- February 2020. Patients with suspected pulmonary tuberculosis on chest radiograph and/or CT thorax, but with sputum smear as well as CBNAAT for Mycobacterium Tuberculosis negative were subjected to flexible video bronchoscopy. Bronchial washings were collected from the affected lobes and the specimen were subjected to fluorescent microscopy, CBNAAT, MGIT, bacterial and fungal culture. Results: The diagnosis of tuberculosis was established in 23 (32.4%) patients in bronchial washings specimen by CBNAAT. These patients were followed up after 6 months of anti-tuberculosis treatment and have shown significant clinical and radiological improvement. Conclusion: Bronchoscopy is a useful tool in diagnosis of pulmonary tuberculosis in sputum negative patients. It also play an important role in diagnosis of other infectious /malignant disorder which can mimic tuberculosis.
Granulomatosis with polyangiitis, previously called Wegener's granulomatosis is the most common form of vasculitis to involve the lung. It can
lead to diverse clinical manifestations frequently involving the upper airways, lungs and kidneys. We report a 59-year-old male patient, who
presented with cough with expectoration and intermittent episodes of blood tinging of sputum for 4 months. Clinically and radiographically a
diagnosis of carcinoma of the lung was made. However, biopsy of the mass came negative for malignancy. C-ANCA tested in the patient came
positive thus establishing a diagnosis of granulomatosis with polyangiitis. The above case is a rare presentation of Granulomatosis with
polyangiitis masquerading as lung cancer
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.