Senecio alpinus L, was recently discovered as the cause of pyrrolizidine alkaloidosis in livestock in Switzerland. A GC-MS analysis of this plant and of hay and silage containing S. alpinus revealed the presence of nine different alkaloids with seneciphylline as the main constituent and senecionine, integerrimine, jacozine, jacobine, jaconine, and the unsaturated analogue of jaconine as minor constituents. The structure of the two other alkaloids are discussed on the basis of their mass spectra.
Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.
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