remaining six program designs can all be considered cost effective depending on what the health-care decision makers are ready to pay for gaining a quality-adjusted life-year. ConClusions: Based on the results of the simulated screening programs, initiation of screening at the age of 75 with repeated screening at 80 years was found to be the most cost-effective design of a screening program for unknown AF when a QALY is considered to be worth approximately € 50,000.
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