Hypersensitive lesions in the skin of sheep, cattle and donkeys from various regions in Israel are described. No cause other than insect bites was found. The animals were free of ticks, lice, fleas and blackflies, and of all the prevailing insect groups; Culicoides spp were considered as the most probable cause of the hypersensitivity. Lesions on the legs and abdomen were attributed mainly to C obsoletus Meigen, C schultzel gp and C puncticollis Becker, and less to C imicola Kieffer. Lesions on the back, flanks, neck and head were attributed mainly to C imicola, less to C newsteadi Austen and rarely to C pulicaris Linnaeus.
Beta-galactosidase-deficient siblings in two litters of English springer spaniel puppies showed a progressive neurological impairment, dwarfism, orbital hypertelorism, and dysostosis multiplex. An excess of GM1-ganglioside was found in the brain. Three abnormal oligosaccharides were present in samples of urine, brain, liver, and cartilage. Light microscopy of selected tissue specimens revealed cytoplasmic vacuoles in neurons, circulating blood cells, macrophages, and chondrocytes. Ultrastructural studies demonstrated that these membrane-bound vacuoles were of two types--one containing lamellated membranes and the other, finely granular material. These clinical and pathological findings are similar to those observed in human patients affected by the infantile form of GM1-gangliosidosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.