The haemoglobin (Hb), red blood cell count (RBC) and haematocrit (Hct) of 11 male rabbits were measured at weekly intervals during a 5-week exposure period to hypobaric hypoxia (simulated altitude, 4,500 m) and the following 4 weeks after restoring normoxic conditions in a climatic chamber at constant temperature. RBC showed the slowest response, Hct the fastest during adaptation to hypoxia and readaptation to normoxia. The body weight decreased during the 1st week at hypoxia and remained at a reduced level for 2 weeks after the return to normoxia. In female rabbits exposed up to 43 days to hypoxia the heart ventricle quotient (HVQ) (weights of left ventricle + septum/right ventricle) was determined. There was a gradual decrease of HVQ expressing the development of right heart hypertrophy which was not stabilised within the observation period.
Inhalt:
Die Injektion von chromosomal markierten Blastozystenzellen in eine normale Rinderblastozyste und die anschließende übertragung auf eine Empfängerkuh führte zur Geburt eines weiblichen Kalbes. Sowohl die 4 möglichen Eltern, als auch das Empfängertier und das erzielte Kalb wurden mit zytogenetischen und biochemischen Methoden untersucht. Im Versuchstier konnte weder durch die zytogenetische Unter‐suchung an Leukozyten, Muskel‐ und Hautrellen, noch durch Blutgruppenuntersu‐chungen, ein Chimärismus festgestellt werden. Die Organisation ekes derartigen Ver‐suches mit Großtieren wird diskutiert.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.