5These authors contributed equally to this work.Received 20.11.14; revised 05.5.15; accepted 22.5.15; Edited by G Melino; published online 03.7.15Abbreviations: Abtb1, ankyrin repeat and BTB (POZ) domain containing 1; ALL, acute lymphoblastic leukemia; Arid3a, AT-rich interactive domain-containing protein 3A; Bak1, BCL2-antagonist/killer 1; Bbc3, BCL2 binding component 3; BCR, B-cell receptor; Blzf1, basic leucine zipper nuclear factor 1; Bmf, Bcl2-modifying factor; BTK, Bruton's tyrosine kinase; CBFB, core-binding factor, β-subunit; EdU, ethynyl-2'-deoxyuridine; Erk, extracellular signal-regulated kinase; GFP, green fluorescent protein; HC, heavy chain; Homez, homeobox and leucine zipper encoding; IL-7, interleukin-7; Irf4, interferon regulatory factor 4; Jnk, c-Jun N-terminal kinase; KD, kinase dead; Lactb, lactamase, β; LAT, linker for activation of T cells; Mdm2, mouse double-minute 2 homolog; MFI, mean fluorescence intensity; miRNA, microRNA; PEI, polyethylenimine; Rag1, recombination activating gene 1; rtTA, tetracycline-regulated reverse transactivator; shRNA, small hairpin RNA; SLP-65, Src homology domain-containing leukocyte protein of 65 kDa; SYK, spleen tyrosine kinase; TNFAIP3, tumor necrosis factor-α-induced protein 3; Trp53inp1, transformation related protein 53 inducible nuclear protein 1; UTR, untranslated region; Rps6ka1, ribosomal protein S6 kinase 1; Sirt7, sirtuin 7; Tmem123, transmembrane protein 123
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