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SummaryWe describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.

Medical making intersects opposing value systems of a medical "do no harm" ethos and makers' drive to innovate. Since March 2020, online maker communities have formed to design, manufacture, and distribute personal protective equipment (PPE) and other medical devices needed to fght the COVID-19 pandemic. We present a participant observation study of 14 maker communities, which have developed difering driving principles for eforts with varied access to interdisciplinary expertise on online platforms that mutually shape collective action. Over time, these communities unintentionally align towards action-oriented or regulated practices because they often lack higher level insight and agency in choosing communication platforms. In response, we recommend: regulatory bodies to build coalitions with makers, online platforms to give communities more control over the presentation of information, and repositories to balance needs to distribute information while limiting the spread of misinformation.

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Maker culture is on the rise in healthcare with the adoption of consumer-grade fabrication technologies. However, little is known about the activities and resources involved in prototyping medical devices to improve patient care. In this paper, we refer to such activity asmedical making to report findings based on a qualitative study of stakeholder engagement in physical prototyping (making) experiences. We examine perspectives from diverse stakeholders including clinicians, engineers, administrators, and medical researchers. Through 18 semi-structured interviews with medical-makers in the US and Canada, we analyze making activity in medical settings. We find that medical makers share strategies to address risks, adopt labor roles, and acquire resources within traditional medical practice. Our findings outline how medical-makers mitigate risks for patient safety, collaborate with local and global stakeholder networks, and overcome constraints of co-location and material practices. We recommend a clinician-aided software system, partially-open repositories, and a collaborative skill-sharing social network to extend their strategies in support of medical making.