No abstract

The attenuating potential of Trévo Dietary Supplement (TDS), a multi-herbal health drink containing 174 ingredients on caffeine-induced sperm toxicities was studied on albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and TDS orally. The treatment lasted for 65 days. Results indicated statistically significant (p<0.05) decreases in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, TDS effectively attenuated the caffeine induced sperm toxicities in albino rat models in a dose dependent manner.

This study was aimed at qualitative evaluation of the ethanol seed, leaf and pulp extracts of C. papaya for bioactive compounds and also to investigate their effect on the haematology in male albino rats. A 3 x 4 factorial experimental layout using randomized complete design was adopted. Results show that the phytochemicals found in seed, leaf and pulp were almost the same but however, in varying proportions. Present result also revealed that there were significant effects (p < 0.05) of the extracts on the heamatology of the treated rats, which was blamed on the varying and different variants ofbioactive compounds found in the extracts they were administered with. Suggestively, C. papaya extracts could be used to enhance the production of selected blood parameters, taking issue of dosage into consideration.

No abstract

This study was aimed at assessing the reproductive activities of male albino rats treated with crude leaf extract of Bougainvillea spectabilis. The total of thirty sexually matured male albino rats of about eleven weeks, weighing between 120-180 g were divided into five groups (A, B, C, D and E) with 6 rats in each group. Rats in group A served as the control and were fed with normal commercial feed only; groups B, C, D and E received 150, 300, 450 and 600 mg kgG 1 Body Weight (BW) of the test substance, respectively. The results of the phytochemistry showed high content of phytates (49.27%) and other bioactive compounds in the leaf extracts. Results on the sperm parameters revealed significant reduction (p<0.05) in the sperm count, viability and motility. Sperm head abnormalities were also significant in the different groups with the highest recorded at 600 mg kgG 1 BW (8.75%). Although, there were no significant difference in the epididymides weight of rats in the different groups, the testes weight was significantly reduced (p<0.05). From the present results, there is a dire need to always apply caution on the use of B. spectabilis in combating diseases considering the possible adverse effects that it could pose on spermatogenic pathways.