Polyenals and polyenones are simple chemical compounds which can be constructed into large and complex structures by virtue of aminocatalysis. In the past eight years, new aminocatalytic activation modes based on trienamine, cross-trienamine, tetraenamine, iminium ion, and vinylogous iminium ion intermediates have attracted great attention in the field of asymmetric synthesis. Key to the increasing focus is their inherent ability to allow functionalization of remote sites with excel-[a] Dr.
Diversity‐oriented synthesis and aminocatalysis constitute two important tools for access to important compounds. The extraordinary development in these two areas has allowed chemists to populate new regions in chemical space. As a consequence, new libraries of complex and diverse frameworks are becoming available for drug discovery. ApDOS is presented as a new concept that shows the scope of aminocatalysis for the synthesis and diversification of privileged structures.
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