A sensitive biosensor has been developed to detect myoglobin (MB), which is an important cardiac biomarker and plays a major role in the diagnosis of acute myocardial infarction (AMI).
Myocardial ischemia/reperfusion (I/R) exacerbates ischemic cell death, in which endoplasmic reticulum (ER) stress and pyroptosis have major implications. Previous evidence showed that the stimulator of interferon genes/ interferon regulatory factor (STING/IRF3) pathway regulates numerous immune and inflammatory responses and is implicated in a range of autoimmune diseases, pathogenic infections, cancer, and cardiovascular diseases. Our most recent study linked STING activation to ER stress and the unfolded protein response (UPR). In addition, STING has a potential role in activating the NOD-like receptor protein 3 (NLRP3)/caspase-1 inflammasome cascade and inducing cell pyroptosis. Therefore, the STING/IRF3 pathway could be a bridge between the upstream ER and oxidative stress and downstream NLRP3/Caspase-1 pathway and pyroptosis and the expression and release of the inflammatory cytokines interleukin-1 (IL-1β) and interleukin-18 (IL-18) triggers, and therefore, myocardial I/R injury. The targeting of STING/IRF3 is of increasing interest in therapeutic agents to reduce I/R injury.
Correction for ‘A fluorescent biosensor for cardiac biomarker myoglobin detection based on carbon dots and deoxyribonuclease I-aided target recycling signal amplification’ by Jishun Chen et al., RSC Adv., 2019, 9, 4463–4468, https://doi.org/10.1039/C8RA09459D.
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