For more than 100 years, the fruit fly
Drosophila melanogaster
has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula
Drosophilae
, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type–related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the
Drosophila
community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.
Highlights d Piezo cell autonomously inhibits axon regeneration in Drosophila sensory neurons d Piezo channels are activated after axon injury or during axon regeneration d Piezo inhibits axon regeneration through calcium signaling, Nos, and PKG d Piezo1 also inhibits axon regeneration in mammals in vitro and in vivo
Sodium channels add variety to inhibitory interneurons Different populations of inhibitory interneurons in the cerebral cortex express distinct subtypes of sodium channels, resulting in diverse action potential thresholds and network excitability.
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