The coastal zone is a precious area that sustains many people and various ecosystems of high biological and economic importance. However, ecosystems and human settlements in coastal regions can be vulnerable to natural disasters such as tsunamis. Around Indonesia, seismic activity under the Indian Ocean has caused frequent earthquakes and tsunamis. In this paper, we describe a GISbased multi-criteria analysis of tsunami vulnerability for the Jembrana Regency in Bali, Indonesia. We used multiple geospatial variables of topographic elevation and slope, topographic relation to tsunami direction, coastal proximity, and coastal shape. We also incorporated expert knowledge by the Analytic Hierarchy Process (AHP) to construct a weighting scheme for the geospatial variables. In order to examine tsunami vulnerability in relation to land use, we overlaid an official land-use map on the tsunami vulnerability map. Buildings as well as residential and agricultural areas were found to be particularly at risk in our study area. GISbased analyses can aid in a wide range of disaster assessment and facilitate regional planning for management and mitigation of natural disasters such as tsunamis. We expect that the tsunami vulnerability map presented here will contribute to preliminary tsunami mitigation and management efforts in the Jembrana Regency.