ABSTRACT:The purpose of this study was to describe clinic-epidemiological characteristics of leishmaniasis cases attended at the Clinical Hospital of Federal University of Uberlândia (CHU), state of Minas Gerais, from January 2000 to December 2013. This is a descriptive and retrospective review of medical records of patients diagnosed with leishmaniasis and treated at the CHU. 168 cases of leishmaniasis were analyzed and most patients were male, aged 23 to 60 years. For cutaneous and mucosal leishmaniasis, single lesions, located mainly in lower limbs and head (CL) and nasal mucosa (ML), were the most common clinical presentation. Regarding the diagnosis, the most performed methods for CL and ML were biopsy plus histopathology and biopsy plus immunohistochemistry; biopsy plus direct parasitological examination methods were the most frequent for VL. Most patients (84%) received treatment, mainly glucantime for both CL and ML; VL treatment was based on amphotericin B or glucantime. According to data from Sistema de Informações de Agravos de Notificação (SINAN), the Brazilian information system to notify and investigate cases of diseases and their aggravations, no case has been confirmed as autochthonous. It is noteworthy the underreporting of cases and the lack of complete information in medical records. Our results may contribute to a better understanding of the real situation in Uberlândia region concerning to leishmaniasis.

ABSTRACT:Affective disorders have been linked to abnormal biological rhythms. Depression-and anxietyrelated behaviors can be altered following changes of daily periods of environmental light. The aim of this study was to investigate the effect of daily light cycle on both anxiety-and depressive-like behaviors of rats. Wistar male rats were exposed to constant dark or constant light during one week and compared to control animals exposed to 12/12h light/dark cycle regarding to anxiety-like behaviors and general activity on open field test and depressive-like behaviors on the forced swimming test. Data showed that rats exposed to one week of constant light exhibited increased number of quadrants crossed in the open field. No change on anxiety-like behaviors (time and quadrants crossed in the center of apparatus) was observed in the open field test. One week of constant dark increased the time of immobility behavior in the forced swimming test relative to control 12/12h light/dark treatment. Therefore, one week of continuous light induced locomotor hyperactivity and one week of continuous dark induced depressive-like behaviors following reestablishment of normal 12/12h light/dark cycle. Such data demonstrate the importance of light/dark environmental rhythm on mood changes and the significance of light/dark cycle control on behavioral studies.