No abstract

This study was conducted to investigate the effects of prebiotic and organic zinc alone and in combination in broiler diets on the live weight gain (LWG), feed consumption (FC), feed consumption ratio (FCR), carcass yield, some relative organ weights and blood parameters. A total of 160 Ross 308 one-day old male chicks were assigned to 4 treatment groups with 4 replicates of 10 birds each. Treatment for each group consisted of: first group (control group) received basal diet without supplementation; second group received 1 g/kg Mannanoligosaccharide (MOS); third group received 80 mg/kg organic zinc (OZn); and fourth group received 80 mg/kg organic zinc + 1 g/kg Mannanoligosaccharide (MOS+OZn). The study lasted 42 days. The supplementation of MOS and OZn had no effect on the LWG, FC, FCR, carcass yield, serum aspartate aminotranferase, (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and triglyceride levels during the experiment (P>0.05). Relative organ weights (liver, spleen, pancreas) were significantly higher in OZn group than those in the other groups (P<0.001). There was a significant difference in serum total cholesterol and glucose levels between treatment groups and control group (P<0.001). Serum Zn and Fe levels were significantly lower in control group than those in OZn and MOS+OZn groups (P<0.001). The highest and the lowest Cu levels were in the MOS+OZn and control groups, respectively (P<0.001). These data suggest that OZn with MOS combination may have a beneficial effect on serum mineral level in broilers.

No abstract

Familial Mediterranean fever (FMF), the most common hereditary autoinflammatory disorder is characterized by recurrent episodes of fever, serositis, arthritis. The major long-term result is amyloidosis. Colchicine remains the principle of the treatment; it not only prevents the acute attacks but also prevents the long-term complications such as amyloidosis; 5-10% of the patients are unresponsive to treatment. Recently new therapeutic options as anti-interleukin 1 agents are successfully used for the patients who do not respond to colchicine treatment. In this study, we retrospectively evaluated 11 pediatric colchicine-resistant FMF patients who were treated with canakinumab. Three of the patients had amyloidosis and two had uveitis. Based on our results, we suggest that canakinumab may be a safe and effective therapy in patients who are resistant to colchicine and even in the patients with amyloidosis. We also suggest that canakinumab might be a safe option for the patients with uveitis.

This research was carried out to determine the effect of Jerusalem artichoke (JA) with or without 5, 10% vetch (V) supplementation on performance, egg quality characteristics and egg cholesterol content. In the study, seventy-five 25 weeks-old commercial white laying hens were randomly divided into one control and 4 treatment groups each containing 15 hens. Control group was fed basal diet without JA or V. Treatment group 1, 2, 3 and 4 were fed diets containing 5% V, 5% JA, 5% JA + 5% V and 10% JA + 10% V, respectively. The feeding period lasted 16 weeks. In the study, it was determined that dried-ground JA contained dry matter, crude protein, ether extract, crude fibre, crude ash, inulin and metabolizable energy (ME) at the level of 93.30, 10.02, 0.36, 5.64, 9.05, 15.80% and 3 060 kcal/kg, respectively. At the end of the study, live weight was lower by 4.36-10.09% in the treatment group 10% JA + 10% V compared with the other groups, but feed efficiency was improved in this group. There were statistically significant differences between the groups in egg quality characteristics (P < 0.05, P < 0.001). Egg production was not affected by supplementation of 5, 10% JA with or without 5, 10% V supplementation. Egg yolk cholesterol and total cholesterol content were not different in the groups (P > 0.05). As a result, the addition of JA with or without V has no adverse effect on performance and egg quality in hens.