Latar belakang. Pasien thalassemia mayor secara progresif akan mengalami keadaan kelebihan besi akibattransfusi darah berulang dan menyebabkan hidroksilasi vitamin D 25-hidroksikolekalsiferol {25(OH)D}terganggu akibat deposisi besi di parenkim hati.Tujuan. Mengetahui korelasi antara kadar feritin dan kadar 25(OH)D pada pasien thalassemia mayor anak.Metode. Desain penelitian rancangan potong lintang dilakukan pada bulan Desember 2010–Januari 2011di poli Thalassemia anak RS. Dr. Hasan Sadikin Bandung. Sejumlah 64 subjek diambil secara consecutivesampling. Data diperoleh dari anamnesis, pemeriksaan fisis, pemeriksaan penunjang, dan catatan medis.Pemeriksaan kadar feritin serum menggunakan metode enhanced chemiluminescence immunoassay (ECLIA).Pemeriksaan kadar 25(OH)D serum menggunakan metode enzyme-linked immunosorbent assay (ELISA) dandilakukan di Laboratory Research and Esoteric Testing Laboratorium Klinik Prodia Jakarta. Analisis statistikdigunakan uji Kolmogorov-Smirnov untuk distribusi data dan transformasi log terhadap distribusi datatidak normal. Untuk mengetahui hubungan antara kadar feritin dan kadar 25(OH)D serum digunakan ujikorelasi Spearman. Hubungan dinyatakan bermakna bila p<0,05.Hasil. Dari 64 subjek berusia 2–14 tahun, didapatkan kadar feritin serum rerata (SB) 3.525 (2.356,784) ng/mL,serta kadar vitamin D 25(OH)D serum rerata (SB) 37 (10,067)nmol/L Enam puluh/enam puluh empat(94%) subjek memiliki kadar feritin serum >1.000 ng/dL, 55/64 (86%) subjek memiliki kadar 25(OH)D serum <50 nmol/L dan dianggap defisiensi vitamin D. Kadar feritin berkorelasi negatif dengan kadar25(OH)D serum (=-0,368; p<0,01).Kesimpulan. Peningkatan kadar feritin serum diikuti penurunan kadar 25(OH)D serum pada pasienthalassemia mayor anak yang berusia 2–14 tahun.
Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ASI terhadap kekebalian bayi dalammasa pandemic Covid-19. Air susu ibu (ASI) merupakan cairan terbaik bagi seorang bayi untuk melindungi bayi dari berbagai penyakit infeksi. Zat kekebalan dalam ASI diantaranya secretory-IgA (sIgA), Lactobacillus bifidus, laktoperoksidase, lisozim, dan lekosit akan menurunkan risiko infeksi pada saluran pencernaan, saluran pernafasan, telinga, diabetes mellitus, dan penyakit alergi. Bayi dengan ASI eksklusif ternyata akan lebih sehat dan lebih jarang sakit dibandingkan dengan yang tidak mendapatkan ASI. Pandemi Coronavirus Disease 2019 (COVID-19) telah memunculkan kekhawatiran tentang apakah ibu yang menderita COVID-19 dapat menularkan SARS-CoV-2 ke bayi atau anak mereka saat menyusui. Organisasi Kesehatan. Ibu harus mendapatkan konsultasi, informasi, dan edukasi bahwa manfaat menyusui secara substansial melebihi potensi risiko penularan. Adanya IgA dalam ASI adalah salah satu cara di mana menyusui melindungi bayi dari infeksi dan kematian. Semua ibu yang pulih dari COVID-19 memiliki antibodi untuk COVID-19 dalam ASI mereka. Berdasarkan penelitian ini dapat disimpulkan bahwa ASI dapat memberikan perlindungan kepada bayi terhadap penyakit infeksi, alergi dan penyakit metabolik melalui berbagai komponen zat kekebalan yang dikandungnya. Jika ibu menyusui dengan terduga infeksi, tidak memberikan ASI akan mengurangi mutrisi dan bayi kehilangan manfaat kekebalan dari ASI tersebut. Air susu ibu mengandung kadar antibodi tipe sekretori tinggi (sIgA), menyusui dari ibu yang pulih dari COVID-19 dapat menurunkan kekebalan ini kepada bay
BACKGROUND Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the newly discovered Coronavirus, namely the SARS-CoV-2 virus. Daily cases of COVID-19 increased rapidly by up to 500% from May 15 to Jun 17, 2021, especially in Banten province; there were 53,472 cases, of which 10.4% were cases of children aged 6-18 years, causing an emergency to prevent the spread of COVID-19. One of the efforts to prevent COVID-19 in children can be through vaccination. Therefore, this study assessed students' attitudes towards the COVID-19 vaccine, evaluated data on COVID-19 vaccinations in students, and assessed the relationship between student attitudes towards the COVID-19 vaccine and COVID-19 vaccination in students. METHODS This study used a cross-sectional design with a population of students from Santa Patricia Junior High School with a sample size of 90 participants using cluster sampling technique and simple random sampling and then analyzed using the exact-fisher test. RESULTSThe results of the study prove that the most prominent characteristic aspects are female gender (64.4%), Age below or equal to 15 years (57.8%), having received the COVID-19 vaccine (86.7%), having a positive attitude towards the COVID-19 vaccine (85.5%), was influenced by other people around him (97.8%) and wanted to vaccinate against COVID-19 (86.7%). Students' attitudes towards the COVID-19 vaccine with COVID-19 vaccination had p=0.324. CONCLUSION The analysis did not show a significant relationship between students' attitudes towards the COVID-19 vaccine and the coverage of the COVID-19 vaccination (p=0.324; p>0.05). KEYWORDS: COVID-19 Vaccine, COVID-19 Vaccination, Junior High School, High School, COVID-19 Pandemic, Theory of Planned Behavior
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.