The current study was aimed to fabricate a transdermal drug delivery system (TDDS) containing Ketoprofen (KTF) and Pregabalin (PGB) for controlled drug release, avoidance of the first-pass metabolism, and increased patient compliance. TDDS of KTF and PGB were formulated using the solvent casting method. Various ratios of hydrophilic polymer (HPMC) and hydrophobic polymers (Eudragit L-100 and Ethyl Cellulose) were employed for the formulation of transdermal patches. PG and oleic acid were used as a permeation enhancer, and PEG-400 was employed as a plasticizer. Surface morphology has confirmed the uniform distribution of drugs throughout the matrix and the excellent compatibility of the selected ingredients. All the formulation showed folding endurance of more than 300, which exhibited that all patches have suitable mechanical strength. One hundred percent flatness also showed good stability of the patches and suitability of the selected ingredients. In vitro drug permeation studies showed more than 97% and 95% release of PGB and KTF, respectively, during the in vitro dissolution studies. The drug release mechanism investigated with various kinetic models exhibited that the rate of drug release was not dependent on initial concentrations of the drug present in the patches and was following the drug diffusion mechanism.
The COVID-19 pandemic has had a significant impact, especially in the last
2 years, and inflicted a grave loss globally. The world came together to devise various
protocols and preventive measures to battle this viral outbreak. The chapter explores
the various immediate medicinal measures to cure COVID infections. The Government
of India initiated the process of vaccine manufacture and distribution among the
population. This was met by various hurdles, namely myths, misconceptions,
misinformation and concerns regarding the vaccines and the disease itself. This was
majorly reported in the rural regions of India where the vaccination was not successful
in the desired results; this might have been due to various reasons, such as lack of
awareness among the rural population or due to the difficulty faced in the
transportation and storage of Corona vaccines. This chapter attempts to shed light on
the acceptance of the COVID-19 vaccines by the Indian population and also discusses
the same concerning the rural population and proposes plans to expedite the Corona
Vaccines to such areas. The Government of India initiated a Co-WIN vaccine delivery
management system to encourage people and create awareness to fight against this
pandemic by opting for vaccination. An independent survey was conducted that
consisted of a questionnaire addressing acceptance, management and concerns about
the COVID-19 vaccination. Among 211 respondents, 19.6% (41 respondents) were
either doctors or medical professionals. The survey provided insight into vaccine
awareness among frontline workers and the general public of India.<br>
The kind of global village that is developing today demands a new 'communication culture' to reshape the upcoming civilization of tomorrow. Communicating with various consumers and types of people from different cultural and ethnic backgrounds would surely be an uphill task for the trades. Using the same language, same framework of communication and the same value systems for catering to the needs of different demographic groups around the world and different segments of consumers would give birth to a 'noncommunication' network.
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