A modular approach for the synthesis of propargylamine modified β-cyclodextrins has been developed through a gold(iii)-catalyzed three-component coupling reaction.
A novel silver-catalyzed transformation of propargylic amine N-oxides with switchable product profiles has been developed. A diversity of enones with excellent E/Z ratios (up to > 20:1) were obtained when the reactions were conducted in aprotic solvents. In contrast, 3-chlorobenzoxymethyl ketones and a-(3-chloro)-benzoxy enones were obtained by using protic solvents. Mechanistic studies suggested that in situ generated isoxazolinium ions are the key intermediates involved in these novel silver-catalyzed reaction pathways. Applications on the chemoselective modification of cysteine-containing peptides in aqueous medium have also been achieved. COMMUNICATIONS Jian-Fang Cui et al. Scheme 2. A proposed reaction mechanism.
Organocatalysts featuring a hydrogen bond donor–acceptor–donor structural element catalyze conjugate addition via complementary DAD–ADA hydrogen bonding.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.