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High erythro-selectivity could be attained in the aldol reaction of ethyl ketones with aldehydes using phenyldichloroborane in the presence of ethyldiisopropylamine.

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Several dZ-camptothecin analogues in which the ethyl group in the E ring of the parent compound 1 is replaced by other side chains were synthesized and their life-span activity in L1210 leukemic mice was tested, dl-Desethylallylcamptothecin (13) was more active than dZ-camptothecin and others.

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