We conclude that animal PET in the setting of the TAA rat model seems to be feasible for the detection of CCA. Future translational studies are needed to confirm and expand our findings.

Surgery may benefit selected GIST patients with PR, SD, and LP, especially for patients with LP because patients with LP had comparable survival to that of patients with responsive lesion. Surgery may prevent potential development of secondary mutations in selected patients with response after IM treatment. Secondary kit mutation was found more frequently in GIST patients with a primary kit exon 11 mutation than those with a primary kit exon 9 mutation.

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Activated mutation of kit constituted 90.7% genetic alteration of Taiwanese with advanced GIST and no PDGFRA mutation was detected. Imatinib induced a sustained objective response in more than half of Taiwan advanced GIST patients. ORR did not differ between patients whose GISTs had no mutation, kit exon 9, and 11 mutations.

The median PFS and OS of 171 GIST patients are 37.6 and 71.0 months, respectively. Poor performance status, tumor size larger than 11.5 cm, primary resistance, and an exon 9 mutation were independently associated with unfavorable PFS. Regarding OS, poor performance status, primary resistance, and tumor size larger than 11.5 cm were three independent unfavorable predictors.

BackgroundHepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and constitutes the leading cause of cancer-related death among men, and second among women in Taiwan. Liver cirrhosis and HCC are relatively prevalent, and 80% to 85% of the patients with these conditions have positive results for hepatitis B surface antigen in Taiwan. Only 5% of the general population is seronegative for all hepatititis B virus (HBV) markers. This is the first study to determine the role of ezrin upon HBV HCC cell and patients with HBV HCC undergoing hepatectomyMethodsImmunohistochemical study with ezrin in 104 human HBV-HCC cases were carried out to investigate its association with the clinicopathological features and the outcomes of 104 HBV-HCC patients undergoing hepatetomy. In addition, DNA constructs including the wild type ezrin (wt-ezrin) and mutant ezrin Tyr353 (Y353) were transfected into Hep3B cell to study its role in tumor invasion and differentiation.ResultsHBV HCC patients with ezrin over-expression independently have smaller tumor size, cirrhotic liver background, poor tumor differentiation, and more vascular invasion. Ezrin expression status has no impact on survival for HBV-HCC patients undergoing hepatectomy. The in vitro assay showed that wt-ezrin Hep3B cells have a significant higher level of AFP secretion and higher invasion ability as compared with the control and Y353- ezrin Hep3B cells.ConclusionEzrin over-expression contributed to de-differentiation and invasion of HBV-HCC cell. HBV-HCC patients with ezrin over-expression were independently associated with tumor with smaller size, cirrhotic liver background, poor differentiation, and vascular invasion.

Sunitinib appears to be an effective treatment for Taiwanese with IM-resistant/intolerant GISTs and induced a sustained clinical benefit in more than 50% of Taiwanese advanced GIST patients.

Moreover, we would like to note that the folded antenna has much smaller size than the unfolded antenna, in addition to the bandwidth improvement in the DCS band.An absolute gain including the return loss and radiation efficiency was measured. The measured radiation patterns for the proposed antenna at 1 and 2 GHz are presented in Figure 6. The radiation patterns of H, E1, and E2 planes were measured in the x-y, z-x, and y-z planes, respectively. In the x-y plane, the radiation pattern at 1 GHz had quite good omni-directional characteristics. The radiation pattern gets more directional in the high-order resonant 2 GHz band. For the GSM and DCS bands, maximum absolute antenna gains (G 0abs ) were Ϫ0.05 and Ϫ0.13 dBi, respectively. These radiation patterns show that the proposed antenna had a good radiation efficiency. CONCLUSIONA dual-band small chip antenna was designed to satisfy requirements for operation in the GSM and DCS bands. The impedance bandwidth and resonant frequency of each band was controlled by the intercoupling capacitance of the metallic structure. The intercoupling capacitance was created by folding a metallic structure. The resonant frequencies were nonuniformly shifted due to the intercoupling capacitance. This property was very useful in controlling the resonance frequencies and their corresponding bandwidths. The simulated and measured results show that the proposed antenna satisfies the requirements for both GSM and DCS bands simultaneously. This resonanceshift effect caused by the folding intercoupling capacitance can be usefully exploited in designing a multiband antenna with high-order resonance phenomena. printed monopole, Electron Lett 28 (1992), 1326 -1327. 4. M. Makimoto and S. Yanashita, Microwave resonator and filters for wireless communication, Springer Verlag, New York, 2000, pp. 84 -87. 5. C.A. Balanis, Antenna theory and analysis and design, Wiley, New York, 2005, pp. 177-217. ABSTRACT: Dielectric resonator-loaded circular microstrip patch antennas can be used as an alternative way to generate circular polarization. The dielectric resonator is placed on the edge of the circular microstrip patch antenna to result both strong coupling effect and two degenerated orthogonal modes. Then, we choose the feeding point, the placed position and size of DR, and the height of antenna as key tuning parameters; both wide circular polarization and impedance matching are achieved. Application is given for WLAN 2.4 GHz band. Both simulated and measured data are matched well. Measured results show that the center frequency is at 2.45 GHz. The impedance bandwidth is 19.2%. Besides, the axial ratio bandwidth is 3.7% (2.39 -2.48 GHz). The radiation patterns are broadside radiations and high antenna gain of 8.6 dBic is achieved.