Drug–drug interaction between esomeprazole at therapeutic and higher doses and sulfonylureas was studied. Sulfonylureas (tolbutamide 40 mg/kg and glibenclamide 40 µg/kg) were administered and the time to onset of hypoglycemia, the duration of the hypoglycemia, and the peak hypoglycemia were determined. Esomeprazole (1.8 mg/kg, 3.6 mg/kg, and 30 mg/kg) was administered for 8 days and its influence on sulfonylurea-induced hypoglycemia was studied. Therapeutic doses of esomeprazole, i.e., 1.8 mg/kg and 3.6 mg/kg dose did not influence the hypoglycemia induced by sulfonylureas. However, a higher dose, i.e., 30 mg/kg, did significantly enhance the duration of hypoglycemia and the peak hypolgycemia. Esomeprazole (30 mg/kg) by itself did not reduce the blood glucose levels; therefore, a pharmacodynamic type of drug interaction can be ruled out. Similarly, a pharmacokinetic type of drug interaction may be ruled out at therapeutic doses. The CYP isoenzyme system involved in the metabolism of sulfonylureas are not very sensitive to esomeprazole and the dose and frequency of administration of sulfonylurea need not be readjusted when they are used concomitantly with esomeprazole (at therapeutic doses).
Purpose:Ayurvedic system of medicine has become significantly more popular all over the globe because of its time tested safety and efficacy. Unprecedented demand for herbal drugs and ignorance of herbal drug collectors-which are mostly collected from wild sources-, has lead to adulteration of genuine drugs which affects the quality of final products.Method:In the present era, authentication and standardization in accordance with Ayurvedic Pharmacopoeia of India (API) is the strategy to ensure the genuineness of medicinal plants used in Ayurveda.Result:Different standard operating procedures are adopted to ensure genuineness, identity and quality of herbal medicines. It is also essential to establish internationally recognized guidelines for ensuring the raw material quality along with Ayurvedic parameters.Conclusion:Based on methods like comparative phytochemical analysis, organoleptic identification, macroscopy, microscopy and TLC of Alpinia species, this paper attempts to illustrate the importance of authentication and standardization of raw materials.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.