Botulinum toxin and derma fillers have made their way into dentistry in recent years for both cosmetic and medicinal purposes. They are here to stay, and with more and more intraoral applications, they are quickly becoming a standard element of dental treatment. They offer the most important, minimally invasive procedures at a cheap cost and with little to no downtime. Botox and derma fillers are used together for rejuvenation and esthetic operations nowadays. The mechanism of action and numerous uses of Botox and derma fillers in the maxillofacial areas, as well as their future implications in dentistry are discussed in this article.