Background Prognosis associated with lymphoma in horses is poorly characterized, and treatment is often palliative. Long‐term outcome after chemotherapy for horses with lymphoma is not well documented. Objective To report long‐term outcome of horses with lymphoma treated with chemotherapy. Animals Fifteen equids. Methods Retrospective case series. Medical record search and call for cases on the ACVIM listserv for horses treated with chemotherapy for lymphoma. Results Fifteen cases with adequate data were identified. Complete remission was achieved in 5 horses (33.3%), partial response was achieved in 9 equids (60%), and stable disease was achieved in 1 horse. Overall response rate was 93.3% (14/15). Overall median survival time was 8 months (range, 1‐46 months). Nine horses experienced a total of 14 adverse effects attributable to chemotherapy. Adverse effects were graded according to the Veterinary Cooperative Oncology Group common terminology criteria for adverse events grading system (grade 1 alopecia, n = 2; grade 1 neutropenia, n = 2; grade 1 lymphopenia, n = 3; grade 1 lethargy, n = 1; grade 2 neurotoxicity, n = 1; grade 2 colic, n = 1; grade 1 hypersensitivity, n = 1; grade 2 hypersensitivity, n = 2; grade 5 hypersensitivity, n = 1). Higher grade adverse effects most commonly were associated with doxorubicin administration (n = 4), including 1 horse that died 18 hours post‐administration. Conclusions and Clinical Importance Chemotherapy can be used successfully for treatment of horses with lymphoma. Adverse effects, most commonly mild, occurred in approximately two‐thirds of treated horses.
Mental health reflects a person's emotional, psychological, and social well-being. A report by World Health Organization suggests that India is the most depressed country in the world. Hence, the idea is to develop an end-to-end solution for identifying and treating mentalhealth issues. This paper aims to develop an application to keep track of user's behaviour, both online and offline, to understand and identify the possible mental health issues using various analytical and psychological methodologies. The target users of this application would be the individuals just above the age of 18 which fall under the category of working class. Postidentification, the user is recommended a suitable change in his routine and behavior which would lead to a better lifestyle.Mental illnesses detection is a challenging undertaking because a misdiagnosis can lead to catastrophic consequences.Hence, our android application will take the necessary steps to accurately identify and treat the mental health issue.
IT IS GENERALLY RECOGNIZED that certain patients form intra-abdominal adhesions after operation or after inflammatory processes. These may produce intestinal obstruction, and at times require surgery. Often adhesions reform and, again, cause obstruction. Methods that might prevent formation or reformation of adhesions have been the subject of several investigations adequately reviewed by Boys1 in I942. Certain of these methods have been of general interest. Rea and Wangensteen,2 Gepfert,3 Totten,4 Merkle,5 and others, introduced amniotic fluid, saline, air, oil, glucose, blood, gum acacia, etc., into the peritoneal cavity to mechanically separate damaged surfaces until reepithelization might occur. Ochsner and Garside,6 Donaldson,7 Ward,8 and others, tried proteolytic enzymes, such as papain or trypsin to digest deposits of fibrin. Lehman and Boys9' 10 employed heparin to minimize the formation of fibrin. Clinical reports of the use of papain by Ochsner,'1 and of heparin by Lehman and BoyS12' 13 and Massie,14 have offered encouragement, but the results are not easily evaluated. Experiments have, therefore, been undertaken to further study the effect of heparin upon the formation and reformation of adhesions. Rabbits, usually male, have been used for all experiments. EXPERIMENTAL METHODS Operations for Prodtuction of Adhesions: Rabbits were anesthetized by intravenous sodium amytal. A midline incision was made, using sterile technic. The appendix was exposed and freed from the meso-appendix using fine silk No. oooooo, for ligation of vessels. The antimesenteric surface was then seared by applying a thin, heated spatula. The peritoneum and the incision were closed by a continuous mattress suture of either fine silk or catgut. The skin was closed with interrupted silk. Operations were performed by several individuals employing this standard technic. Operations for Division of Adhesions: Celiotomies were performed through the same midline incision two weeks, or more, after the searing and at varying intervals thereafter, to determine occurrence and extent of adhesions and to divide and study reformation of adhesions. Adhesions were divided, using blunt dissection for closely adherent surfaces or sharp dissection with division and ligation for longer bands.
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