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BACKGROUND: Low back pain (LBP) is a common presenting complaint affecting mostly middle aged and older person and traditionally considered as ageing process, but now-a-days large number of younger people are also affected by this debilitating chronic disorder. The cause of early onset of degenerative spine disease is multifactorial, but genetical predisposition plays very important role. AIMS AND OBJECTIVE: To find out association between genetic predisposition and degenerative spine disease in adult patients and to assess the pattern of MRI findings of various degenerative diseases in lumbo-sacral spine. MATERIAL AND METHOD: The present cross-sectional study had been performed among 100 selected patients in 1yr period, who presented with chief complaint of chronic low back pain. After taking detailed clinical and professional history, MRI of lumbosacral spine had been performed. Total 100 patients were divided in two groups on the basis of genetical predisposition. Prevalence and spectrum of degenerative changes were compared between both groups. RESULTS: Hundred patients of 20 to 35-year age had been selected with mean age of 27yr. Out of 100 patients; 47 were male and 53 were female. The most common degenerative findings were desiccation of disc (95%) followed by disc bulge, herniation, spinal canal stenosis, ligamentum flavum hypertrophy, facet joint hypertrophy and modic changes. L4-L5 and L5-S1 were the most commonly involved spinal levels for any degenerative pathology. CONCLUSION: Good association is seen between early onset of degenerative spine disease and genetical predisposition in patients who have history of similar type degenerative spine disease in one or more first degree relatives in comparison to those patients who do not have any genetical predisposition. So it can be concluded that heredity play important role in early onset of degenerative spine disease in adults.

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BACKGROUNDSpinal cord housed and protected by vertebral column, hence injury to vertebral column endanger the function of spinal cord and half of the spinal column injury associated with spinal cord injury. In our study, we are comparing two method of spinal column fixation in thoracolumbar spinal column injury as incidence of dorsolumbar injuries accounted for 75% of all spine injuries.

To collect data of bone mineral density of young Indian adults and to assess the effect of different factors on bone mineral density in them. METHODS: The study design in which T-score data of 304 athletes and 300 sedentary young Indian adults of age 18-30 yrs was collected. Recorded of their per capita income and three days meal pattern, to assess calcium intake, was collected. RESULTS: This study depicts that sedentary young adults fail to acquire adequate peak bone mass and become osteopenic as early as age 25, especially females while athletes achieve much higher values of bone mineral density as compared to their Caucasian counterparts. Per capita Income <1000rs./mth results in lower bone mineral density, affecting sedentary ones more than the athletes. Calcium intake <500mg/day negatively affects bone mineral density. However, levels above this value do not have any direct relationship with positive effect on bone mineral density. CONCLUSION: Indian young adults achieve much less peak bone as compared to their western counterparts. That is why the prevalence of osteoporosis is much higher amongst Indians. Though, Indian are not genetically predisposed to have low peak bone mass. Rather, it is the lack general adults awareness reflected through lack of exercise and low socio economic status (secondarily affecting the dietary calcium), which results in poor bone health among young Indian adults. These young individuals can attain peak bone mass higher than their western counterparts with regular exercise program.