Nanofiber has become one of tissue engineering examples and has extensive application on medical field, particularly as a wound healing and wound dressing. In this research, nanofiber composite based on polycaprolactone and collagen was successfully obtained via electrospinning process and further developed as host of naproxen as anti-inflammatory agents. Addition of copper ferrite (CuFe 2 O 4 ) nanoparticles on the nanocomposite becomes an advance part on this study to control of naproxen release. Several characterizations were furnished to prove the design composite nanofiber and its drug release analysis performed to find out the kinetic model and naproxen release mechanism from nanofibers. CuFe 2 O 4 nanoparticles have potential to be used to control naproxen release in nanofiber that lead to decrease level of drug released, where mostly follow the Korsmeyer-Peppas model. The release of naproxen was certainly influenced by pH value, in which the drug was easier to release on base, instead of acid or neutral condition. Varied naproxen and nanoparticle compositions were prepared to reach optimum formulation of the release. This study provides fundamental data for the effect of magnetic nanoparticle on drug release process.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.