We know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.
Survival analysis in the presence of multiple possible adverse events, i.e., competing risks, is a pervasive problem in many industries (healthcare, finance, etc.). Since only one event is typically observed, the incidence of an event of interest is often obscured by other related competing events. This nonidentifiability, or inability to estimate true cause-specific survival curves from empirical data, further complicates competing risk survival analysis. We introduce Siamese Survival Prognosis Network (SSPN), a novel deep learning architecture for estimating personalized risk scores in the presence of competing risks. SSPN circumvents the nonidentifiability problem by avoiding the estimation of cause-specific survival curves and instead determines pairwise concordant time-dependent risks, where longer event times are assigned lower risks. Furthermore, SSPN is able to directly optimize an approximation to the C-discrimination index, rather than relying on well-known metrics which are unable to capture the unique requirements of survival analysis with competing risks.
Neural networks are being increasingly used for efficient decision making in the aircraft domain. Given the safety-critical nature of the applications involved, stringent safety requirements must be met by these networks. In this work we present a formal study of two neural network-based systems developed by Boeing. The Venus verifier is used to analyse the conditions under which these systems can operate safely, or generate counterexamples that show when safety cannot be guaranteed. Our results confirm the applicability of formal verification to the settings considered.
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