AimThe primary aim of this study was to identify the level of stress and the stressors having an impact on nurses compared with other medical workers in private IVF centres.BackgroundStressful working conditions can an adversely affect not only the health and well‐being of health professionals but also subsequently to patient outcomes if care is given to infertile couples. This is of relevance particularly in view of Vietnam's recent economic growth and the increase in the number of private IVF centres. This is the first study looking at the levels of stress experienced by health workers (especially nurses) providing IVF services.DesignA cross‐sectional survey.MethodsAll health workers in seven IVF Clinics in HCMC were invited to complete an Occupational Stress Index (OSI) questionnaire.ResultsOf the invited 131 medical professionals, 105 (80%) completed the confidential self‐administered questionnaire. Thirty‐five participants (33.3%) were nurses, 19 (18.1%) were doctors and 51 (48.6%) were lab technicians. Approximately two‐thirds reported not having children (67.6%), half (50.48%) married and three‐quarters (76.2%) were women, with a significant difference by medical worker group (p < 0.05). Among the three groups, nurses have higher occupational stress index score compared with the others. The OSI score only had a strong relationship with the “high demand” (p < 0.001). Some demographic variables (e.g., income, long working hours, education level) statistically represented the high significant source of job stress.
OBJECTIVE: Although uterine leiomyomas (LM) and leiomyosarcomas (LMS) are considered biologically unrelated tumors, both share morphological and histological characteristics that complicate their differential diagnosis. The development of accurate and non-invasive differential diagnostic methods in patients with surgical indication is urgently needed. Here, we aim to identify targetable mutations in LMS vs LM using Next Generation Sequencing (NGS) to advance our knowledge in their differential diagnosis. DESIGN: Research clinical study analysing tumour specimens (n¼21) from patients diagnosed with uterine LM and/or LMS. MATERIALS AND METHODS: Targeted sequencing of DNA and RNA coding regions for 170 solid tumours associated-genes (TST170, Illumina, USA) was performed on formalin-fixed, paraffin-embedded (FFPE) samples from LM and LMS specimens. DNA sequencing data were assessed by TST170 DNA analysis workflow to identify copy number variations (CNVs), single nucleotide variants (SNVs) and small insertions/deletions (indels). TST170 RNA analysis workflow was also used to get gene expression profile as well as gene fusions and splice variants. RESULTS: Tumor mutation burden was higher in terms of CNVs, SNVs, indels, and gene fusions in LMS vs LM specimens. For CNVs, 17 genes were affected by deletions in LMS samples, compared to 5 observed losses in LM. Gains (duplications) were also more frequently identified in LMS, present in 13 genes vs 1 gene with duplication within LM cohort. The most common e64
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