Tuberculosis (TB) is one of the deadliest infectious diseases which is caused by the Mycobacterium tuberculosis. A group of first line anti-TB drugs namely isoniazid, rifampicin, pyrazinamide and ethambutol have been accepted for the treatment of drug susceptible tuberculosis. A topological index is a molecular structure descriptor which is a numerical value associated with chemical constitution for correlation of a chemical structure with its properties. The aim of this work is to investigate some degree-based topological indices for the above-mentioned anti-TB drugs using a polynomial approach. The molecular graphs of these anti-TB drugs structures were used to derive the M-Polynomials and then the derived formulas were used to calculate topological indices of the respective structures. This research could facilitate the design of new medicines against these pathogenic bacteria.
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