The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
The relationship between changes in GFR and sodium and water reabsorption by the proximal tubule was studied in 11 control dogs and 8 dogs with salt retention produced by 5 days of DOCA administration. Fractional reabsorption by the proximal tubule was determined by recollection micropuncture before and after aortic constriction. Constriction produced significant and similar decreases in renal perfusion pressure, GFR, and RPF in control dogs and dogs with salt retention. Fractional reabsorption by the proximal tubule was significantly increased following constriction in control dogs but not in dogs with salt retention. The difference between the two groups was significant, P < 0.001. Plasma renin activity was significantly lower in dogs with salt retention before and after constriction, however, the percent increase in plasma renin activity after constriction was not different between the two groups. It is concluded that changes in GFR are accompanied by proportionate changes in reabsorption by the proximal tubule in dogs with salt retention.
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