Cancer is one of the leading causes of death in the world. It is the main reason why research in this field becomes challenging. Not only for the pathologist but also from the view of a computer scientist. Hematoxylin and Eosin (H&E) images are the most common modalities used by the pathologist for cancer detection. The status of cancer with histopathology images can be classified based on the shape, morphology, intensity, and texture of the image. The use of full high-resolution histopathology images will take a longer time for the extraction of all information due to the huge amount of data. This study proposed advance texture extraction by multi-patch images pixel method with sliding windows that minimize loss of information in each pixel patch. We use texture feature Gray Level Co-Occurrence Matrix (GLCM) with a meanshift filter as the data pre-processing of the images. The mean-shift filter is a low-pass filter technique that considers the surrounding pixels of the images. The proposed GLCM method is then trained using Deep Neural Networks (DNN) and compared to other classification techniques for benchmarking. For training, we use two hardware: NVIDIA GPU GTX-980 and TESLA K40c. According to the study, Deep Neural Network outperforms other classifiers with the highest accuracy and deviation standard 96.72±0.48 for four cross-validations. The additional information is that training using Theano framework is faster than Tensorflow for both in GTX-980 and Tesla K40c.

Breast cancer is diagnosed using histopathological imaging. This task is extremely time-consuming due to high image complexity and volume. However, it is important to facilitate the early detection of breast cancer for medical intervention. Deep learning (DL) has become popular in medical imaging solutions and has demonstrated various levels of performance in diagnosing cancerous images. Nonetheless, achieving high precision while minimizing overfitting remains a significant challenge for classification solutions. The handling of imbalanced data and incorrect labeling is a further concern. Additional methods, such as pre-processing, ensemble, and normalization techniques, have been established to enhance image characteristics. These methods could influence classification solutions and be used to overcome overfitting and data balancing issues. Hence, developing a more sophisticated DL variant could improve classification accuracy while reducing overfitting. Technological advancements in DL have fueled automated breast cancer diagnosis growth in recent years. This paper reviewed studies on the capability of DL to classify histopathological breast cancer images, as the objective of this study was to systematically review and analyze current research on the classification of histopathological images. Additionally, literature from the Scopus and Web of Science (WOS) indexes was reviewed. This study assessed recent approaches for histopathological breast cancer image classification in DL applications for papers published up until November 2022. The findings of this study suggest that DL methods, especially convolution neural networks and their hybrids, are the most cutting-edge approaches currently in use. To find a new technique, it is necessary first to survey the landscape of existing DL approaches and their hybrid methods to conduct comparisons and case studies.

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