Our previous experiments in rats have failed to demonstrate any stimulative effect of Pitressin on the thyroid activities but rather showed suppressive one, indicated by T/S ratio, 131I uptake, histological examination1) and plasma PB131I concentration2), as their parameters. CROSSON, FALCH and REICHLIN also reported the failure in stimulating the thyroids of rats by
Exogenous neurohypophysial preparations have been reported to exert stimulative1-6), or suppressive6-8), or no influence8-12) on the thyroid function. Our previous investigation on the effects of Pitressin on the rat's thyroid function using T/S ratio, 131 I uptake and histological examination as its parameters failed to demonstrate any stimulative effect of the hormone, but inhibitory effect on the increase in the activity provoked by cold exposure8). Recently GARCIA et al. 5) reported an elevation of plasma PB 131 I concentration during the infusion of the neurohypophysial preparations in the Lthyroxine-treated conscious rabbits, which was reconfirmed by us under almost identical experimental design 13. In the experiments of L-thyroxine-treated
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