Paper sludge ash (PS ash) discharged from Fuji area, Shizuoka prefecture reach about 160,000 tons/ year. Therefore, the development of a technique for utilizing of PS ash is essential for recycling waste materials.PS ash collected in Fuji area has little of SiO2 and much Al2O3, CaO, in comparison with the general material of the artificial zeolite (e.g. coal fly ash). PS mainly consists of calcite, talc and kaolinite, which
We investigate the compositions of vesicle formulation by assembling phase diagrams of the ternary components of lauroyl‐glutamyl‐lysil‐lauroyl‐glutamate (C12‐GLG‐C12) peptide‐based gemini‐type amphiphile/citric acid/water using visual and microscopic observations. To clarify interactions between C12‐GLG‐C12 and citric acid, turbidity and zeta potential of the mixtures were investigated. To improve the stability of metastable vesicles, appropriate additives were examined by measuring particle size and zeta potential, visual observation and transmission electron microscopy. The turbidity increased and the absolute value of zeta potential decreased with increasing citric acid concentration in C12‐GLG‐C12/citric acid solutions. Then, a metastable γ region having vesicles was formed. The stability of vesicles increased with increasing cholesterol concentrations. This result suggests that a coacervation has occurred due to the effective cross‐sectional area decreasing with increasing C12‐GLG‐C12 hydrophobicity, which was derived from inhibition of the carboxyl group dissociation. Furthermore, we hypothesized that the orientation of cholesterol between vesicle membranes is a contributing factor to improve the vesicle stability. From transmission electron microscopic observations, it was made clear that the vesicles consisting of cholesterol and C12‐GLG‐C12 at a molar ratio of 2:1 showed multilayered structures. The vesicles consisting of C12‐GLG‐C12, cholesterol and citric acid are expected to be used as transdermal drug delivery system carriers, as they can be easily prepared using biocompatible compounds without the use of organic solvents such as chloroform.
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