L-Lysine production was studied in continuous culture with a single-stage cultivation process using the L-lysine hyperproducing mutant B-6 of Corynebacterium glutamicum. showed stable L-lysine production for over 500 h.The maximum values of L-lysine-HC1 concentration and volumetric productivity were 105 g/1 and 5.6 g/1 per hour, respectively. The latter corresponded to a 2.5-fold higher value than that of a fed-batch culture. Higher agitation or use of oxygen-enriched air was critical for high productivity. This indicates that oxygen supply greatly affects L-lysine productivity in continuous culture.

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