No abstract

No abstract

Hepatic artery vascular responsiveness to altered portal blood flow is blunted in cirrhotic livers.

The mudstone of the Yezo Group exposed in Central Hokkaido yields abundant microfossils of calcareous nannofossils, foraminifers, radiolarians and dinoflagellates. Benthic foraminifers consisting of both agglutinated and calcareous species occur abundantly and consistently throughout the sequence, while specimens of planktonic foraminifers are generally fewer than benthics in all samples. We recognized the following 13 planktonic foraminiferal zones

The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NETosis). Human peripheral blood neutrophils and platelets were co-incubated with or without LPS (0.2 μg/ml) in the presence and absence of rTM (2 μg/ml). NETosis was confirmed by immunostaining and confocal microscopy. In the absence of platelets, LPS did not induce NETosis in the neutrophils. NETosis, however, was induced by LPS when neutrophils were co-cultured with platelets (64 % of neutrophils). Notably, rTM was able to fully inhibit NETosis in neutrophils cultured with platelets and in the presence of LPS. rTM did not induce NETosis in this co-culture system (p < 0.01 versus LPS in the absence of rTM). These results show that rTM can suppress LPS-induced platelet-dependent NETosis in vitro.