RESUMEN En el presente trabajo se describen las caracteristicas del método de datación por tennoluminiscencia, su fundamento y una aplicación a un yacimiento español, en concreto el denominado «Fábrica de Ladrillos», situado en el ténnino municipal de Getafe (Madrid), y correspondiente a la facies Cogotas 1. Se presentan las fechas obtenidas, así como su interpretación dentro del entorno cultural. ABSTRACT This paper deals with the characteristics of thermoluminescent dating, the physical processes underlying it, and its application to the Cogotas 1 culture site of Fabrica de Ladrillos (Getafe, Spain). The absolute dates are presented, and their archaeological interpretation within the context of Cogotas 1 is discussed.
, conscientes del gran vacío con que en temas de datación absoluta han venido trabajando los investigadores de nuestra comunidad científica. La plasmación en realidad de este objetivo, es decir, el montaje y puesta a punto de un laboratorio de datación absoluta por TL en nuestra Universidad fue posible gracias a la concesión por parte de la D.G.I.C.YT. del proyecto coordinado n.° PB-87-0091, C02-00 el cual de forma muy resumida pretendía tres objetivos básicos: 1. Diseño del equipo experimental. 2. Construcción y puesta a punto de una cadena de TL.
university hospital. Patients 0-35 days old treated with gentamicin and with plasma concentrations (Cp) were reviewed. The descriptive analysis was performed with the SPSSV.24 programme. Results 47 patients with a median age of 3 days (0-33) were studied, 33 male. 26 (55.3%) were <1 week old. 34 (72.3%) were admitted for neonatal sepsis and 7 (14.9%) for urinary infection. Gentamicin was used in combination with ampicillin in 45 cases (95.7%) and empirically in 34 (72.3%). The initially prescribed dose was 4 mg/kg/day in 36 (77%) and 5 mg/kg/day in 8 (17%), with no differences in weeks of life. Cp were extracted with a median of 2 days (1-4) after the start, the median peak was 7.5 mg/L (3.5-21.6) and 29 (62%) had a peak <8 mg/L. The trough was <0.2 mg/L in 26 patients and of those that were quantified, the median was 0.4 mg/L (0.2-1.3), and was higher than 1 mg/L in only one case. It was recommended to increase the dose in 26 (55.3%) and reduce it in 4 (8.5%) patients, with 90% acceptance. A second Cp determination was requested in 16 (34%) cases with a median peak of 9 mg/L (6-12) and trough levels always <0.5 mg/L. It was recommended to increase the dose in 5 cases with an acceptance of 94%. Conclusion and relevance The dose prescribed was lower than recommended in neonates >1 week old. Cp allowed detection and correction of deviations from the recommended peak or trough levels in 64% of cases, mainly due to low peak levels, with high acceptance of TDM. Plasma determination and TDM of gentamicin continues to be an essential tool to achieve the recommended PK/PD profile.
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