Exposure of in vitro preparations of rat and rabbit ileum to gamma -rays from a 60Co source elicited significant increases in tension and in amplitude of the normal contractions. In most cases the reaction could not be repeated, indicating an inactivation or depletion of some active substance. In addition, dose levels of 3000 rads were sufficient to depress cholinesterase activity. Since this dose is too small to inactivate the enzyme significantly the mechanism appears to be one of depletion of it from the tissues.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.