ABSTRACT. An absolute reduction of the plasma cortisol levels and a delay of the peak concentrations were recorded in 10 healthy subjects, when a bile‐sequestering anionic exchange resin, cholestyramine, was given prior to a single oral hydrocortisone dose, indicating that the resin interferes with the uptake of a neutral sterol in the human gastrointestinal tract. The possibility of a direct binding of drug to resin is supported by the affinity of hydrocortisone to cholestyramine in vitro, which was uninfluenced by the presence of sodium taurocholate. Cholestyramine significantly delayed the gastric emptying of a glucose solution, indicating that the resin not only decreases but also delays hydrocortisone absorption. Careful supervision is recommended when treatment with cholestyramine is given concomitant to neutral sterol drugs.
It has long been well known that a sufficiently high concentration of magnesium ions in the tissues causes a condition resembling that of anaesthesia (JOLYET and CAHOURS, 1869). A great many investigations seem to show that this magnesium anaesthesia is due, in part at least, to an obstruction of neuromuscular transmission ( W m , 1906; BARDIER, 1907 ; MATTHEWsand BROOKS 1910, and others). Other observers, however, are of opinion that the activity of the central nervous system is also reduced (MELTZER and AUER, 1905 and later). A more complete survey is availablein works by GRAM, 1919; ESKELUND, 1931 and ENOBZK, 1948. Hitherto it has not been clearly demonstrated which of the two mechanisms takes predominales in the anaesthesia.In this paper we attempt to contribute to the knowledge of the mechanism of magnesium anaesthesia. We have examined the effect of various possible antagonists, such as neostigmine, pentamethylenetetrazol and j?-phenylisopropylamine. (1933) found that the respiration of experimental animals in magnesium anaesthesia was stimulated by different analeptics. A still stronger effect was obtained by injection of eserine (JOSEPH and MELTZER, 1909 ; STARKENSTEIN, 19 14 ; ESKE- LUND, 1931). Consequently eserine is reported t o increase the M. L. D. of magnesium. On the other hand magnesium also Actn plinrniacologira vol. 5 , fiw. 4.
TOSCANO RICO
14 dagar var pat. ILter i arbete men var nu psykiskt forandrad. Han kande sig osaker, ofta litet oklar, och han var benagen for grubbel. Samtliga symtom var dock sB latta a t t han mycket bra klarade ett kvalificerat arbete. Fr. 0. m. sommaren 1952 accentuerades symtomen markaut, och frBn oktober 1952 fram till iiitagningen i deceniber samma i r var pat. totalt arbetsoformogen.Sista tiden fiire intagningen p i klinikcn dominerades bilden av en tillta-
1) Frin psykintriska klinikcn i Lund (chef: professor Erik Essen-Mdller).Nord J Psychiatry Downloaded from informahealthcare.com by Mcgill University on 11/20/14For personal use only.
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