The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development since then has transformed from a low-budget, government-supported research effort to a high-stakes, multi-billion dollar industry. The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. This article chronicles the history of modern chemotherapy and identifies remaining challenges for the next generation of researchers.

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We present a theoretical and experimental comparison of spontaneous parametric down-conversion in periodically poled waveguides and bulk KTP crystals. We measured a waveguide pair generation rate of 2.9.10(6) pairs/s per mWof pump in a 1-nm band: more than 50 times higher than the bulk crystal generation rate.