The inventor figures succeeded in contributing to people's lives and making people's lives developed with the findings of the inventor figures, but there are still many people who do not know and know the inventor figures, people only know the objects found by the inventor figures but do not know who the characters find the objects. that thing. The introduction of the inventor character is one of the reference materials that can be used to introduce the inventor character. In this day and age, android-based inventor character recognition applications are very efficient to use. In making a character recognition application, strings can be implemented for the word search process. String can be interpreted as an approach how to find the pattern of arrangement of string characters in other strings or part of the body of text. String has several algorithms, one of which is the Sequential Search algorithm where this algorithm is a very simple search algorithm that is carried out by comparing data one by one from a predetermined data set (Array) until the data is completed (found) or there is no match (not found). ). This inventor character recognition application is designed by utilizing the setudio android software. So that the application is easier to use and can be used independently anywhere and anytime.
Latar belakang : Proses inflamasi berperan penting dalam patogenesis SLE. Proses inflamasi yang terjadi pada penderita SLE juga akan mempengaruhi diferensiasi osteoklas dan osteoblast. Interleukin-17 (IL-17) merupakan mediator pro-inflamasi yang dihasilkan akibat proses inflamasi sistemik. Peningkatan kadar sitokin pro-inflamasi diketahui mengakibatkan perubahan regulasi RANKL, yang selanjutnya akan mempengaruhi osteoprotegerin (OPG). Peningkatan kadar sitokin pro-inflamasi pada penderita SLE dapat mengakibatkan ketidakseimbangan RANKL/OPG.
Tujuan : Mengetahui korelasi antara kadar IL-17 serum dengan rasio RANKL/OPG pada penderita SLE.
Metode : Penelitian ini merupakan studi observasional analitik potong lintang yang dilakukan di poliklinik dan bangsal rawat inap. Penyakit Dalam RSUP Sanglah Denpasar, Bali, Indonesia dari bulan Januari-Maret 2018. Penderita SLE berjenis kelamin wanita yang berusia lebih dari 18 tahun dan belum mengalami menopause serta bersedia mengikuti penelitian dengan menandatangani informed consent diikutsertakan dalam penelitian. Kadar IL-17 serum diperiksa dengan menggunakan metode high sensitivity ELISA (Enzyme-linked immunosorbent assay). RANKL diukur menggunakan metode Human sRANKL (TOTAL) ELISA, sedangkan OPG diukur menggunakan metode Human Osteoprotegerin ELISA. Rasio RANKL/OPG didapatkan dari perbandingan antara kadar RANKL dan OPG.
Hasil : Penelitian ini melibatkan 68 subyek penelitian. Median umur subyek penelitian yaitu 31,32 (17-54). Kadar IL-17 dan rasio RANKL/OPG pada seluruh subyek yaitu 0,435 (0,23-30,65) dan 70,18 (4,98-1060,46). Didapatkan korelasi yang bermakna antara kadar IL-17 dan rasio RANKL/OPG dengan p=0,010. Dari analisis multivariat didapatkan bahwa kadar IL-17 berkorelasi dengan rasio RANKL/OPG (B=6,554, SE(B)=2,686, p=0,018).
Simpulan : Pada penelitian ini terdapat korelasi antara kadar IL-17 serum dengan rasio RANKL/OPG pada penderita SLE.
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