Introduction. Adenoid (acantholytic) squamous cell carcinoma (ASCC) is a histological variant of squamous cell carcinoma which occurs mainly in the sun-exposed areas of the head and neck region. It is commonly seen among males which mainly occurs in the sixth and seventh decade of life with lip being predominately affected. Limited scientific literature is documenting the intraoral presentation of ASCC in contrast to its usual extraoral lesions associated with the skin. Characteristic pseudo glandular alveolar space formation seen in ASCC often mimics carcinoma of salivary gland origin. In-depth knowledge of histopathological features of ASCC is important to diagnose this uncommon variant. Case Description. An 80-year-old female presented with the chief complaint of the nonhealing lesion in the right lower back region of the jaw for 2 months, associated with pain. A provisional diagnosis of oral cancer was considered, and an incisional biopsy was done. Histopathological presentation of the epithelial tumor island, pseudo glandular duct-like structures, and neoplastic cells showing features of dysplasia and keratin pearl formation confirmed the diagnosis as adenoid (acantholytic) squamous cell carcinoma. Conclusion. The histopathological presentation of adenoid (acantholytic) squamous cell carcinoma reflects the prognosis and metastatic behavior of the diseases. The knowledge of histopathological features of ASCC would be a guide to the untrained eye for the diagnosis and management of this uncommon variant to minimize the rate of metastasis or reoccurrence.
Basaloid squamous cell carcinoma (BSCC) is a rare, distinctive, and aggressive variant of squamous cell carcinoma (SCC) primarily seen in the upper aerodigestive tract with epiglottis, soft palate, and base of the tongue being site of high preference in head and neck region. It differs from conventional SCC histologically and immunologically, is most frequently found in males in their sixth and seventh decades, and is frequently linked to alcohol and tobacco use. High stage disease with distant metastases, a high recurrence rate, and a dismal prognosis is how BSCC typically manifests. In the present article, we report four cases of BSCC.
Trauma within the oral cavity is one of the common incidence of occurrence which can be an inducer as well as propagator for wide range of oral lesion of diverse course. A unique combination of formation of granulomatous lesion with reactive eosinophilic stromal infiltration in response of trauma is “traumatic ulcerative granuloma with stromal eosinophilia (TUGSE)”. It is a reactive, infrequent, self-limiting condition of oral mucosa. The commonly involved site and the clinical presentation might click to suspect it as a lesion of oral cancer. Clinical history and examination guide through the diagnosis whereas histopathology forms the basis of the diagnosis.
Intra-osseous pathology of the craniofacial region is microscopically characterized by hypercellular fibroblastic stroma with a variable amount of bone or cementum like calcified structures. The overlapping histopathological features are not limited to lesions under one classification of similar origin rather it imbricates the lesions of entirely different origin as well. The only possible way out then becomes the clinicopathological correlation. Hence, in an out of entire clinical, a radiographic, surgical, and histopathological feature reframes the building block for confirmatory diagnosis of a bone lesion.
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